Adrenal Cortical Steroids—Advances in Research and Application: 2013 Edition is a ScholarlyBrief™ that delivers timely, authoritative, comprehensive, and specialized information about Glucocorticoids in a concise format. The editors have built Adrenal Cortical Steroids—Advances in Research and Application: 2013 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Glucocorticoids in this book to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Adrenal Cortical Steroids—Advances in Research and Application: 2013 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.

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The hypothalamic-pituitary-adrenal axis controls reactions to stress and regulates various body processes such as digestion, the immune system, mood and sexuality, and energy usage. This volume focuses on the role it plays in the immune system and provides substantive experimental and clinical data to support current understanding in the field, and potential applications of this knowledge in the treatment of disease. - Evidence presented in this book suggests that the nervous, endocrine, and immune systems form the Neuroendoimmune Supersystem, which integrates all the biological functions of higher organisms both in health and disease for their entire life cycle - Contributors include both the scientists who initiated the work on the HPA axis and on the autonomic nervous system, and those who joined the field later

Glucocorticoids regulate multiple metabolic and developmental processes and play a vital role in the maintenance of basal and stress-related homeostasis. For the last 50 years, pharmacologic doses of glucocorticoids have been used in the treatment of inflammatory, autoimmune, and lymphoproliferative diseases and in the prevention of allograft rejection, while substitution doses have been employed in the management of adrenocortical insufficiency. aspects of glucocorticoid action, in particular, (i) the impact of maternal and early life stress on stress-related gene regulation in the offspring; (ii) the importance of glucocorticoids and their receptors; (iii) further understanding of the mechanisms of GR action, including its effect on chromatin modulation, its interaction with coactivators and corepressors, and the genetic dissection of GR function in mice; (iv) The interaction of hGR with other transcription factors, such as NF-kappa-B, p53, transforming growth factor beta (TGF-beta) and the chicken ovalbumin upstream promoter transcription factor II (COUP-TFII); recycling, ubiquitination and degradation of the receptor, actions of the GR-beta isoform, a novel synthetic nonsteroidal target gene-specific agonist, the importance of target tissue activity of 11-beta-hydroxysteroid dehydrogenase type 1 in glucocorticoid action in health and disease, the interaction of the receptor with the nutrient carnitine, the anthrax products protective antigen (PA) and lethal factor (LF), and the human immunodeficiency virus type-1 (HIV-1)-encoded molecules Vpr and Tat; (vi) an update on the effects of glucocorticoids on the immune system; and (vii) the clinical implications of glucocorticoid action, including glucocorticoid resistance/hypersensitivity, familial and sporadic glucocorticoid resistance, and the effects of stress and depression.

Recent Progress in Hormone Research, Volume 33 covers the Proceedings of the 1976 Laurentian Hormone Conference. The book discusses the expanding significance of hypothalamic peptides; the LATS in Graves' disease; and the ontogenesis of hypothalamic-pituitary-thyroid function and metabolism in human, sheep, and rat. The text also describes the antimullerian hormone; the evolution of gonadotropin structure and function; and the biosynthesis of parathyroid hormone. The carbon-13 nuclear magnetic resonance investigations of hormone structure and function; the regulation of vasopressin function in health and disease; and some considerations of the role of the antidiuretic hormone in water homeostasis are also considered. The book further tackles the clinical significance of circulating proinsulin and C-peptide; glucagon and the A cells; and a newly recognized pancreatic polypeptide. The text then encompasses the steroid hormone actions in tissue culture cells and cell hybrids and their relation to human malignancies; and the role of hormones on digestive and urinary tract carcinogenesis. Endocrinologists, neuroendocrinologists, and oncologists will find the book invaluable.

Recent Progress in Hormone Research, Volume I covers the proceedings of the Laurentian Hormone Conference, held in Mont Tremblant, Quebec. This symposium brings together theoretical and experimental studies on the various aspects of hormone research. This book is organized into four sections encompassing 13 chapters. The opening section deals first with the role of acetylcholine in the mechanism neuro-humoral activity, followed by an overview of the dependence of mating activities on particular endocrine secretions. The succeeding two sections describe the chemical, physiological, and metabolic aspects of adrenal hormones. The last section surveys the relation of the hormones to human osteogenesis and carcinogenesis. This section also looks into the factors influencing the rate and duration of child growth. This book will prove useful to endocrinologists and developmental biologists.

Imaging of the adrenal gland has made tremendous progress in the last decade as new technologies continue to evolve. Adrenal Imaging highlights the pertinent clinical and pathological information that underpins the accurate interpretation and use of adrenal imaging. Written by a prestigious group of international contributors, individual chapters in Adrenal Imaging serve as a relevant and up-to-date reference of adrenal imaging findings, algorithms and techniques in CT, MR nuclear medicine, intervention and trauma. Summary sections at the end of each chapter illuminate key teaching points to enhance retention.

Recent Progress in Hormone Research, Volume 25 presents the proceedings of the 26th meeting of the Laurentian Hormone Conference held in Mont Tremblant, Quebec, Canada, on August 23-29, 1968. The book presents papers on reproductive endocrinology (i.e. a model for the regulation of ovulation in the rat; comparative aspects of uterine-luteal relationships), proinsulin (i.e. proinsulin and the biosynthesis of insulin), and the secretion of hormones by tumors of nonendocrine origin (i.e. clinical and laboratory studies of ectopic humoral syndromes). The text also includes papers on the ultrastructure of the endocrine glands; on the thyroid (i.e. studies of the thyroid iodide ""trap"" in human); on neuroendocrinology (i.e. the mammalian pineal as a neuroendocrine transducer), and on steroid hormones (i.e. metabolic events associated with steroid hydroxylation by the adrenal cortex; and steroid dynamics under steady-state conditions). Endocrinologists and people involved in hormone research will find the book invaluable.