Accelerated Path to Cures provides a transformative perspective on the power of combining advanced computational technologies, modeling, bioinformatics and machine learning approaches with nonclinical and clinical experimentation to accelerate drug development. This book discusses the application of advanced modeling technologies, from target identification and validation to nonclinical studies in animals to Phase 1-3 human clinical trials and post-approval monitoring, as alternative models of drug development. As a case of successful integration of computational modeling and drug development, we discuss the development of oral small molecule therapeutics for inflammatory bowel disease, from the application of docking studies to screening new chemical entities to the development of next-generation in silico human clinical trials from large-scale clinical data. Additionally, this book illustrates how modeling techniques, machine learning, and informatics can be utilized effectively at each stage of drug development to advance the progress towards predictive, preventive, personalized, precision medicine, and thus provide a successful framework for Path to Cures.

Accelerated Path to Cures provides a transformative perspective on the power of combining advanced computational technologies, modeling, bioinformatics and machine learning approaches with nonclinical and clinical experimentation to accelerate drug development. This book discusses the application of advanced modeling technologies, from target identification and validation to nonclinical studies in animals to Phase 1-3 human clinical trials and post-approval monitoring, as alternative models of drug development. As a case of successful integration of computational modeling and drug development, we discuss the development of oral small molecule therapeutics for inflammatory bowel disease, from the application of docking studies to screening new chemical entities to the development of next-generation in silico human clinical trials from large-scale clinical data. Additionally, this book illustrates how modeling techniques, machine learning, and informatics can be utilized effectively at each stage of drug development to advance the progress towards predictive, preventive, personalized, precision medicine, and thus provide a successful framework for Path to Cures.

Geraint is a Financial Strategist, specializing in helping families achieve financial freedom by helping them create additional streams of passive income. He is also the Creator of The Financial Freedom Program (TFFP), a 60 minutes consultation to help families achieve financial freedom and the Founder of FirstHomeFinance.sg, a Financial Education Website for future and current home owners. After witnessing many of his loved ones suffer from poor financial advice, he is dedicated to pursue his vision and mission of creating a financially educated, empowered, and enlightened society, where everyone helps each other out by paying forward what they have learnt. Through this book, he aims to give you absolute clarity on the fundamentals of personal finance by developing a blueprint called the Financial Success Map. He also aims to equip you with the necessary skills and knowledge to prevent you from making the top ten financial mistakes that numerous people are currently making, and that you might be making as well. Besides identifying these mistakes that have hindered many from reaching the financial success they had been looking for their entire lives, he also gives you practical tips that you can apply immediately to improve your financial situation.

As medical devices become more intricate, with an increasing number of components made from a wide range of materials, it is important that they meet stringent requirements to ensure that they are safe to be implanted and will not be rejected by the human body. Joining and assembly of medical materials and devices provides a comprehensive overview of joining techniques for a range of medical materials and applications.Part one provides an introduction to medical devices and joining methods with further specific chapters on microwelding methods in medical components and the effects of sterilization on medical materials and welded devices. Part two focuses on medical metals and includes chapters on the joining of shape memory alloys, platinum (Pt) alloys and stainless steel wires for implantable medical devices and evaluating the corrosion performance of metal medical device welds. Part three moves on to highlight the joining and assembly of medical plastics and discusses techniques including ultrasonic welding, transmission laser welding and radio frequency (RF)/dielectric welding. Finally, part four discusses the joining and assembly of biomaterial and tissue implants including metal-ceramic joining techniques for orthopaedic applications and tissue adhesives and sealants for surgical applications.Joining and assembly of medical materials and devices is a technical guide for engineers and researchers within the medical industry, professionals requiring an understanding of joining and assembly techniques in a medical setting, and academics interested in this field. - Introduces joining methods in medical applications including microwelding and considers the effects of sterilization on the resulting joints and devices - Considers the joining, assembly and corrosion performance of medical metals including shape memory alloys, platinum alloys and stainless steel wires - Considers the joining and assembly of medical plastics including multiple welding methods, bonding strategies and adhesives

The future of medicine is happening now. Revolutionary new science is providing cures that were considered science fiction just a few years ago—and not with pills, surgery, or radiation, but with human cells. Promising treatments now in extensive clinical trials could have dramatic impacts on cancer, autoimmune diseases, organ replacement, heart disease, and even aging itself. The key to these breakthroughs is the use of living cells as medicine instead of traditional drugs. Discover the advances that are alleviating the effects of strokes, Alzheimer's disease, and even allergies. Cells Are the New Cure takes you into the world of regenerative medicine, which enables doctors to repair injured and aging tissues and even create artificial body parts and organs in the lab. Cellular medicine experts Robin L. Smith, MD, and Max Gomez, PhD, outline the new technologies that make it possible to harness the immune system to fight cancer and reverse autoimmune diseases like multiple sclerosis, type 1 diabetes, and rheumatoid arthritis. CRISPR, a new technology for targeted gene editing, promises to eradicate genetic diseases, allowing us to live longer lives—possibly even beyond age 100 in good health. Cells Are the New Cure takes you on a tour of the most exciting and cutting-edge developments in medicine. The content inside these pages could save your life or the life of someone you love.

Finally, after a century apart, Julia and Charlie begin building a life together. But once again, their plans for a future are thwarted when Charlie displays puzzling side effects of his supernatural existence as the Phoenix. As his symptoms progress and Julia runs out of options, they are forced to seek out the only other immortal they know—Charlie’s former captor, Amara. Darius and Amara go back millennia. Having drunk from the murderous Fountain of Youth, their history is marred by deadly choices. Amara is desperate to have Darius back but he cannot forgive her for the part she played in unleashing the Fountain of Youth on the world or for what the water made her do. When Julia gets wind of Amara’s insidious plan to redeem herself, she finds that an enemy of an enemy is a friend. After saving her life, Darius reveals the truth about Charlie’s existence as the Phoenix, including the fact that this time, Julia can’t save the only man she’s ever loved. Armed with nothing but a shadowy foretelling about the Phoenix, Julia discovers that with Charlie and his newfound abilities they may be able to stop Amara from unleashing her treachery on the world. The only problem is they have no idea how. Even if they could figure it out, will the cost of bringing Amara down be too high?