Research centering on blood flow in the heart continues to hold an important position, especially since a better understanding of the subject may help reduce the incidence of coronary arterial disease and heart attacks. This book summarizes recent advances in the field; it is the product of fruitful cooperation among international scientists who met in Japan in May, 1990 to discuss the regulation of coronary blood flow.

This presentation describes various aspects of the regulation of tissue oxygenation, including the roles of the circulatory system, respiratory system, and blood, the carrier of oxygen within these components of the cardiorespiratory system. The respiratory system takes oxygen from the atmosphere and transports it by diffusion from the air in the alveoli to the blood flowing through the pulmonary capillaries. The cardiovascular system then moves the oxygenated blood from the heart to the microcirculation of the various organs by convection, where oxygen is released from hemoglobin in the red blood cells and moves to the parenchymal cells of each tissue by diffusion. Oxygen that has diffused into cells is then utilized in the mitochondria to produce adenosine triphosphate (ATP), the energy currency of all cells. The mitochondria are able to produce ATP until the oxygen tension or PO2 on the cell surface falls to a critical level of about 4–5 mm Hg. Thus, in order to meet the energetic needs of cells, it is important to maintain a continuous supply of oxygen to the mitochondria at or above the critical PO2 . In order to accomplish this desired outcome, the cardiorespiratory system, including the blood, must be capable of regulation to ensure survival of all tissues under a wide range of circumstances. The purpose of this presentation is to provide basic information about the operation and regulation of the cardiovascular and respiratory systems, as well as the properties of the blood and parenchymal cells, so that a fundamental understanding of the regulation of tissue oxygenation is achieved.

An illuminating grand tour through the profound teachings of A Course in Miracles, by one of its most respected teachers and scholars. Writing in the warm, accessible style that has become his trademark, Robert Perry is our guide as we explore the extraordinary journey set out in the Course. And it is an extraordinary journey - from our beginnings in eternity, to our primordial separation, to our journey home and our return, at last, to the Heart of God. Robert's perceptive teaching inspires us to experience first-hand the pivotal milestones of this journey - the forgiveness, holy instants, and miracles that speed our return to the peace we seek.Return to the Heart of God is arguably Robert's most important and ambitious work to date. A work in which he explores, with all his customary virtuosity, and in fascinating detail, the extraordinary journey set out in the Course.Robert Perry has done a masterful job of presenting the true heart and soul of A Course in Miracles in a way that offers hope and healing.

Mary Ellen Geist decided to leave her job as a CBS Radio anchor to return home to Michigan when her father's Alzheimer's got to be too much for her mother to shoulder alone. She chose to live her life by a different set of priorities: to be guided by her heart, not by outside accomplishment and recognition. The New York Times wrote a front page story on Mary Ellen on Thanksgiving 2005. It was one of the most e-mailed stories for the month. Through her own story and through interviews with doctors and other women who've followed the "Daughter Track"--leaving a job to care for an aging parent--Geist offers emotional insights on how to encourage interaction with the loved one you're caring for; how to determine daily tasks that are achievable and rewarding; how the personality of the patient affects the caregiving and the progression of the diseases; as well as invaluable advice about how caregivers can take care of themselves while accomplishing the Herculean task of constantly caring for others. Geist's years in journalism allow her to report on Boomers' caretaking dilemmas with professional objectivity, and her warm voice brings compassion and insight to one of the most difficult stituations a son or daughter may face during his or her life.

#1 NEW YORK TIMES BESTSELLER • In her latest book, Brené Brown writes, “If we want to find the way back to ourselves and one another, we need language and the grounded confidence to both tell our stories and be stewards of the stories that we hear. This is the framework for meaningful connection.” Don’t miss the five-part HBO Max docuseries Brené Brown: Atlas of the Heart! In Atlas of the Heart, Brown takes us on a journey through eighty-seven of the emotions and experiences that define what it means to be human. As she maps the necessary skills and an actionable framework for meaningful connection, she gives us the language and tools to access a universe of new choices and second chances—a universe where we can share and steward the stories of our bravest and most heartbreaking moments with one another in a way that builds connection. Over the past two decades, Brown’s extensive research into the experiences that make us who we are has shaped the cultural conversation and helped define what it means to be courageous with our lives. Atlas of the Heart draws on this research, as well as on Brown’s singular skills as a storyteller, to show us how accurately naming an experience doesn’t give the experience more power—it gives us the power of understanding, meaning, and choice. Brown shares, “I want this book to be an atlas for all of us, because I believe that, with an adventurous heart and the right maps, we can travel anywhere and never fear losing ourselves.”

The Social Security Administration (SSA) uses a screening tool called the Listing of Impairments to identify claimants who are so severely impaired that they cannot work at all and thus immediately qualify for benefits. In this report, the IOM makes several recommendations for improving SSA's capacity to determine disability benefits more quickly and efficiently using the Listings.

Long ago we humans used a form of communication and sensing that did not involve the brain in any way; rather, it came from a sacred place within our hearts. What good would it do to find this place again? This is a book of remembering. You have always had this place within your heart, and it is still there now. It existed before creation, and it will exist even after the last star shines its brilliant light. At night when you enter your dreams, you leave your mind and enter the sacred space of your heart. But do you remember? Or do you only remember the dream? Why am I telling you about this "something" that is fading from our memories? What good would it do to find this place again in a world where the greatest religion is science and the logic of the mind? Don't I know where emotions and feelings are second-class citizens? Yes, I do. But my teachers have asked me to remind you who you really are. You are more than just a human being, much more. For within your heart is a place, a sacred place, where the world can literally be remade through conscious cocreation. If you really want peace of spirit and if you want to return home, I invite you into the beauty of your own heart. With your permission, I will show you what has been shown to me. I will give you the exact instructions to the pathway into your heart where you and God are intimately one. It is your choice. But I must warn you: Within this experience resides great responsibility. Life knows when a spirit is born to the higher worlds, and life will use you as all the great masters who have ever lived have been used. If you read this book and do the meditation and then expect nothing to change in your life, you may get caught spiritually napping. Once you have entered the light of the great darkness, your life will change -- eventually, you will remember who you really are.

Although cardiac output is measured as the flow of blood from the left ventricle into the aorta, the system that controls cardiac output includes many other components besides the heart itself. The heart’s rate of output cannot exceed the rate of venous return to it, and therefore, the factors governing venous return are primarily responsible for control of output from the heart. Venous return is affected by its pressure gradient and resistance to flow throughout the vascular system. The pressure gradient for venous return is a function of several factors including the blood volume flowing through the system, the unstressed vascular volume of the circulatory system, its capacitance, mean systemic pressure, and right atrial pressure. Resistance to venous return is the sum of total vascular resistance from the aortic valve to the right atrium. The sympathetic nervous system and vasoactive circulating hormones affect short-term resistance, whereas local tissue blood flow autoregulatory mechanisms are the dominant determinants of long-term resistance to venous return. The strength of contraction of the heart responds to changes in atrial pressure driven by changes in venous return, with small changes in atrial pressure eliciting large changes in strength of contraction, as described by the Frank–Starling mechanism. In addition, the autonomic nervous system input to the heart alters myocardial pumping ability in response to cardiovascular challenges. The function of the cardiovascular system is strongly affected by the operation of the renal sodium excretion–body fluid volume–arterial pressure negative feedback system that maintains arterial blood pressure at a controlled value over long periods. The intent of this volume is to integrate the basic knowledge of these cardiovascular system components into an understanding of cardiac output regulation. Table of Contents: Introduction / Venous Return / Cardiac Function / Integrated Analysis of Cardiac Output Control / Analysis of Cardiac Output Regulation by Computer Simulation / Analysis of Cardiac Output Control in Response to Challenges / Conclusion / References / Author Biography

On October 29, 1908, a party of four men, led by Ernest Shackleton, set out to be the first to reach the South Pole. Three months later, their mission was in ruins and they faced certain death if they carried on. Just ninety-seven miles from the South Pole, Shackleton turned back. One hundred years later, in October 2008, a team that included descendants of that original party, led by Henry Worsley, set out from Shackleton’s hut to celebrate the centenary of his expedition by retracing the exact 870-mile route and going on to finish the last ninety-seven miles. This captivating book explores the history of the original expedition and reasons behind its failure, while capturing the meticulous planning, fundraising, and training for the new expedition. It includes riveting accounts of the team’s first days on the ice, Christmas on the polar plateau, the brutal reality of crossing the Beardmore Glacier, and the final miles to the South Pole. In Shackleton's Footsteps is a unique story of adventure, pioneering spirit, settling old family business, and man’s triumph over nature.