In one of the most entertaining and twisty thrillers of the year a London family, a mother, father and young son, must deal with the murder of their secretive next door neighbor and the intrusive police investigation that follows. Readers will be faced with ever shifting and increasingly frightening suspicions that one or all of them had something to do with it. Alex Mercer loves his family more than anything. His wife Millicent and their precocious eleven-year-old son Max are everything to him, his little tribe. When he is with them all is right with the world. But when he and Max find their next door neighbour dead in his bathtub, their lives are suddenly and irrevocably changed. Max is surprisingly fascinated by the dead body, and Alex is understandably anxious about how Max will react later, once he takes it all in. And Alex is increasingly impatient for the police to conclude their investigation and call this the suicide that it so clearly was. But as new information surfaces, it becomes clear that there is more to this than anyone is saying... Why was the neighbour charging his home improvements to the Mercers’ address? How did Millicent’s bracelet end up in his apartment? And why, in fact, did Max lead his father into the house on the quiet summer night that they found the corpse? As suspicion grows between the three, the once close-knit family starts to disintegrate. Is Alex really the loving husband we believe him to be? And where is Millicent really going when she disappears for hours, walking the parks of London, stewing over something that she can’t forget? Each of them is suffering. Each has something to hide. And as each questions how well they really know each other, they must decide how far they’ll go to protect themselves-and each other-from investigators who are watching every move they make. Just waiting for someone to make a mistake.

The placenta is an organ that connects the developing fetus to the uterine wall, thereby allowing nutrient uptake, waste elimination, and gas exchange via the mother's blood supply. Proper vascular development in the placenta is fundamental to ensuring a healthy fetus and successful pregnancy. This book provides an up-to-date summary and synthesis of knowledge regarding placental vascular biology and discusses the relevance of this vascular bed to the functions of the human placenta.

Research centering on blood flow in the heart continues to hold an important position, especially since a better understanding of the subject may help reduce the incidence of coronary arterial disease and heart attacks. This book summarizes recent advances in the field; it is the product of fruitful cooperation among international scientists who met in Japan in May, 1990 to discuss the regulation of coronary blood flow.

This presentation describes various aspects of the regulation of tissue oxygenation, including the roles of the circulatory system, respiratory system, and blood, the carrier of oxygen within these components of the cardiorespiratory system. The respiratory system takes oxygen from the atmosphere and transports it by diffusion from the air in the alveoli to the blood flowing through the pulmonary capillaries. The cardiovascular system then moves the oxygenated blood from the heart to the microcirculation of the various organs by convection, where oxygen is released from hemoglobin in the red blood cells and moves to the parenchymal cells of each tissue by diffusion. Oxygen that has diffused into cells is then utilized in the mitochondria to produce adenosine triphosphate (ATP), the energy currency of all cells. The mitochondria are able to produce ATP until the oxygen tension or PO2 on the cell surface falls to a critical level of about 4–5 mm Hg. Thus, in order to meet the energetic needs of cells, it is important to maintain a continuous supply of oxygen to the mitochondria at or above the critical PO2 . In order to accomplish this desired outcome, the cardiorespiratory system, including the blood, must be capable of regulation to ensure survival of all tissues under a wide range of circumstances. The purpose of this presentation is to provide basic information about the operation and regulation of the cardiovascular and respiratory systems, as well as the properties of the blood and parenchymal cells, so that a fundamental understanding of the regulation of tissue oxygenation is achieved.

A German Jewish girl whose life is destroyed by the atrocities of World War II . . . her uncle, who undermines the sureties of his own life in order to fight for Israeli statehood . . . the Jews of a 15th-century Italian ghetto . . Othello, newly arrived in Venice . . . a young Ethiopian Jewish woman resettled in Israel. These are the extraordinary people who inhabit Caryl Phillips' eloquent and moving new novel, and whose stories are connected by circumstance, spirit, and blood across the centuries.

"Told with brains and heart" —Michelle Gable, New York Times bestselling author of A Paris Apartment "Bristles with charm and curiosity" —Winston Groom, New York Times bestselling author of Forrest Gump "A wholly original and superbly crafted work of art, Beasts of Extraordinary Circumstance is a masterpiece of the imagination." —Lori Nelson Spielman, New York Times bestselling author of The Life List and Sweet Forgiveness "Charlotte's Web for grown-ups who, like Weylyn Grey, have their own stories of being different, feared, brave, and loved." —Mo Daviau, author of Every Anxious Wave Ruth Emmie Lang teaches us how to find magic in the ordinary in her magical realism debut Beasts of Extraordinary Circumstance. Orphaned, raised by wolves, and the proud owner of a horned pig named Merlin, Weylyn Grey knew he wasn’t like other people. But when he single-handedly stopped that tornado on a stormy Christmas day in Oklahoma, he realized just how different he actually was. As amazing as these powers may appear, they tend to manifest themselves at inopportune times and places, jeopardizing not only his own life, but the life of Mary, the woman he loves. Beasts of Extraordinary Circumstance tells the story of Weylyn Grey’s life from the perspectives of the people who knew him, loved him, and even a few who thought he was just plain weird. Although he doesn’t stay in any of their lives for long, he leaves each of them with a story to tell: great storms that evaporate into thin air; fireflies that make phosphorescent honey; a house filled with spider webs and the strange man who inhabits it. There is one story, however, that Weylyn wishes he could change: his own. But first he has to muster enough courage to knock on Mary’s front door.

The Grammy- and Academy Award- nominated singer-songwriter's haunting, lyrical memoir, sharing the story of an unthinkable act of violence and ultimate healing through art Mobile, Alabama, 1986. A fourteen-year-old girl is awakened by the unmistakable sound of gunfire. On the front lawn, her father has shot and killed her mother before turning the gun on himself. Allison Moorer would grow up to be an award-winning musician, with her songs likened to "a Southern accent: eight miles an hour, deliberate, and very dangerous to underestimate" (Rolling Stone). But that moment, which forever altered her own life and that of her older sister, Shelby, has never been far from her thoughts. Now, in her journey to understand the unthinkable, to parse the unknowable, Allison uses her lyrical storytelling powers to lay bare the memories and impressions that make a family, and that tear a family apart. Blood delves into the meaning of inheritance and destiny, shame and trauma -- and how it is possible to carve out a safe place in the world despite it all. With a foreword by Allison's sister, Grammy winner Shelby Lynne, Blood reads like an intimate journal: vivid, haunting, and ultimately life-affirming.

This e-book will review special features of the cerebral circulation and how they contribute to the physiology of the brain. It describes structural and functional properties of the cerebral circulation that are unique to the brain, an organ with high metabolic demands and the need for tight water and ion homeostasis. Autoregulation is pronounced in the brain, with myogenic, metabolic and neurogenic mechanisms contributing to maintain relatively constant blood flow during both increases and decreases in pressure. In addition, unlike peripheral organs where the majority of vascular resistance resides in small arteries and arterioles, large extracranial and intracranial arteries contribute significantly to vascular resistance in the brain. The prominent role of large arteries in cerebrovascular resistance helps maintain blood flow and protect downstream vessels during changes in perfusion pressure. The cerebral endothelium is also unique in that its barrier properties are in some way more like epithelium than endothelium in the periphery. The cerebral endothelium, known as the blood-brain barrier, has specialized tight junctions that do not allow ions to pass freely and has very low hydraulic conductivity and transcellular transport. This special configuration modifies Starling's forces in the brain microcirculation such that ions retained in the vascular lumen oppose water movement due to hydrostatic pressure. Tight water regulation is necessary in the brain because it has limited capacity for expansion within the skull. Increased intracranial pressure due to vasogenic edema can cause severe neurologic complications and death.

The Blood Books are now available in "Blood Ties" TV tie-in editions. View our TV tie-in feature page here here. Vicki Nelson has received the call that no daughter ever wants to receive—that her mother has died. Marjory Nelson’s coworkers at the Queen’s University Life Science Department told her that she suffered a heart attack, and that they’d be waiting for Vicki to arrive in Kingston to make the funeral arrangements. But what begins as a personal tragedy turns into the most terrifying case of Vicki’s career, when her mother’s body disappears mysteriously from the funeral home. Someone at the University is determined to learn the secret of life after death…and they’ve decided to make Vicki’s mother part of their horrifying experiments.