In this New York Times bestseller and longlist nominee for the National Book Award, “our greatest living chronicler of the natural world” (The New York Times), David Quammen explains how recent discoveries in molecular biology affect our understanding of evolution and life’s history. In the mid-1970s, scientists began using DNA sequences to reexamine the history of all life. Perhaps the most startling discovery to come out of this new field—the study of life’s diversity and relatedness at the molecular level—is horizontal gene transfer (HGT), or the movement of genes across species lines. It turns out that HGT has been widespread and important; we now know that roughly eight percent of the human genome arrived sideways by viral infection—a type of HGT. In The Tangled Tree, “the grandest tale in biology….David Quammen presents the science—and the scientists involved—with patience, candor, and flair” (Nature). We learn about the major players, such as Carl Woese, the most important little-known biologist of the twentieth century; Lynn Margulis, the notorious maverick whose wild ideas about “mosaic” creatures proved to be true; and Tsutomu Wantanabe, who discovered that the scourge of antibiotic-resistant bacteria is a direct result of horizontal gene transfer, bringing the deep study of genome histories to bear on a global crisis in public health. “David Quammen proves to be an immensely well-informed guide to a complex story” (The Wall Street Journal). In The Tangled Tree, he explains how molecular studies of evolution have brought startling recognitions about the tangled tree of life—including where we humans fit upon it. Thanks to new technologies, we now have the ability to alter even our genetic composition—through sideways insertions, as nature has long been doing. “The Tangled Tree is a source of wonder….Quammen has written a deep and daring intellectual adventure” (The Boston Globe).

A masterpiece of science reporting that tracks the animal origins of emerginghuman diseases.

"Quammen brilliantly and powerfully re-creates the 19th century naturalist's intellectual and spiritual journey."--Los Angeles Times Book Review Twenty-one years passed between Charles Darwin's epiphany that "natural selection" formed the basis of evolution and the scientist's publication of On the Origin of Species. Why did Darwin delay, and what happened during the course of those two decades? The human drama and scientific basis of these years constitute a fascinating, tangled tale that elucidates the character of a cautious naturalist who initiated an intellectual revolution.

"David Quammen is simply the best natural essayist working today."--Tim Cahill, author of Lost in My Own Backyard "Lively writing about science and nature depends less on the offering of good answers, I think, than on the offering of good questions," said David Quammen in the original introduction to Natural Acts. For more than two decades, he has stuck to that credo. In this updated version of curiosity leads him from New Mexico to Romania, from the Congo to the Amazon, asking questions about mosquitoes (what are their redeeming merits?), dinosaurs (how did they change the life of a dyslexic Vietnam vet?), and cloning (can it save endangered species?). This revised and expanded edition best-loved "Natural Acts" columns, which first appeared in Outside magazine in the early 1980s, and includes recent pieces such as "Planet of Weeds," an influential new Natural Acts is an eye-opening journey that will please both Quammen fans and newcomers to his work. Song lyrics have been redacted from this ebook owing to permissions issues.

"Rich detail and vivid anecdotes of adventure....A treasure trove of exotic fact and hard thinking." —New York Times Book Review For millennia, lions, tigers, and their man-eating kin have kept our dark, scary forests dark and scary, and their predatory majesty has been the stuff of folklore. But by the year 2150 big predators may only exist on the other side of glass barriers and chain-link fences. Their gradual disappearance is changing the very nature of our existence. We no longer occupy an intermediate position on the food chain; instead we survey it invulnerably from above—so far above that we are in danger of forgetting that we even belong to an ecosystem. Casting his expert eye over the rapidly diminishing areas of wilderness where predators still reign, the award-winning author of The Song of the Dodo and The Tangled Tree examines the fate of lions in India's Gir forest, of saltwater crocodiles in northern Australia, of brown bears in the mountains of Romania, and of Siberian tigers in the Russian Far East. In the poignant and troublesome ferocity of these embattled creatures, we recognize something primeval deep within us, something in danger of vanishing forever.

A majority of evolutionary biologists believe that we now can envision our biological predecessors--not the first, but nearly the first, living beings on Earth. This book is about these vanished forebears. The era between the first rudimentary life on Earth and the appearance of more complex beings is called the RNA world. It is RNA (ribonucleic acid) long believed to be a mere biologic copier and messenger, that offers a glimpse into our ancient predecessors. To describe early RNA creatures, here called "ribocytes" or RNA cells, the author uses basics of molecular biology. He reviews our current understanding of the tree of life, examines the structure of RNA itself, explains the operation of the genetic code, and more. Courting controversy among those who question the role of ribocytes -- citing the chemical fragility of RNA and the uncertainty about the origin of an RNA synthetic apparatus -- he offers a vision of early life on Earth.

This is the story of a profound revolution in the way biologists explore life's history, understand its evolutionary processes, and reveal its diversity. It is about life's smallest entities, deepest diversity, and greatest cellular biomass: the microbiosphere. Jan Sapp introduces us to a new field of evolutionary biology and a new brand of molecular evolutionists who descend to the foundations of evolution on Earth to explore the origins of the genetic system and the primary life forms from which all others have emerged. In so doing, he examines-from Lamarck to the present-the means of pursuing the evolution of complexity, and of depicting the greatest differences among organisms. The New Foundations of Evolution takes us into a world that classical evolutionists could never have imagined: a deep phylogeny based on three domains of life and multiple kingdoms, and created by mechanisms very unlike those considered by Darwin and his followers. Evolution by leaps seems to occur regularly in the microbial world where molecular evolutionists have shown the inheritance of acquired genes and genomes are major modes of evolutionary innovation. Revisiting the history of microbiology for the first time from the perspective of evolutionary biology, Sapp shows why classical Darwinian conceptions centering on questions of the origin of species were forged without a microbial foundation, why classical microbiologists considered it impossible to know the course of evolution, and classical molecular biologists considered the evolution of the molecular genetic system to be beyond understanding. In telling this stirring story of scientific iconoclasm, this book elucidates how the new evolutionary biology arose, what methods and assumptions underpin it, and the fiery controversies that continue to shape biologists' understanding of the foundations of evolution today.

This book tells the dramatic story of Crispr and the potential impact of this gene-editing technology.

While viruses—the world’s most abundant biological entities—are not technically alive, they invade, replicate, and evolve within living cells. Michael Cordingley goes beyond our familiarity with infections to show how viruses spur evolutionary change in their hosts and shape global ecosystems, from ocean photosynthesis to drug-resistant bacteria.

ONE OF NPR’S BEST BOOKS OF 2019 A “warm and funny and honest…genuinely unputdownable” (Curtis Sittenfeld) memoir chronicling what it’s like to live in today’s world as a fat man, from acclaimed journalist Tommy Tomlinson, who, as he neared the age of fifty, weighed 460 pounds and decided he had to change his life. When he was almost fifty years old, Tommy Tomlinson weighed an astonishing—and dangerous—460 pounds, at risk for heart disease, diabetes, and stroke, unable to climb a flight of stairs without having to catch his breath, or travel on an airplane without buying two seats. Raised in a family that loved food, he had been aware of the problem for years, seeing doctors and trying diets from the time he was a preteen. But nothing worked, and every time he tried to make a change, it didn’t go the way he planned—in fact, he wasn’t sure that he really wanted to change. In The Elephant in the Room, Tomlinson chronicles his lifelong battle with weight in a voice that combines the urgency of Roxane Gay’s Hunger with the intimacy of Rick Bragg’s All Over but the Shoutin’. He also hits the road to meet other members of the plus-sized tribe in an attempt to understand how, as a nation, we got to this point. From buying a Fitbit and setting exercise goals to contemplating the Heart Attack Grill in Las Vegas, America’s “capital of food porn,” and modifying his own diet, Tomlinson brings us along on a candid and sometimes brutal look at the everyday experience of being constantly aware of your size. Over the course of the book, he confronts these issues head-on and chronicles the practical steps he has to take to lose weight by the end. “What could have been a wallow in memoir self-pity is raised to art by Tomlinson’s wit and prose” (Rolling Stone). Affecting and searingly honest, The Elephant in the Room is an “inspirational” (The New York Times) memoir that will resonate with anyone who has grappled with addiction, shame, or self-consciousness. “Add this to your reading list ASAP” (Charlotte Magazine).