In Vitro Methods in Pharmaceutical Research provides a comprehensive guide to laboratory techniques for evaluating in vitro organ toxicity using cellular models. Step-by-step practical tips on how to perform and interpret assays for drug metabolism and toxicity assessment are provided, along with a comparison of different techniques available. It is a welcome addition to the literature at a time when interest is growing in cellular in vitro models for toxicology and pharmacology studies. - Meets the continuing demand for information in this field - Compares In Vitro techniques with other methods - Describes cell-culture methods used to investigate toxicity in cells derived from different organs - Includes contributions by leading experts in the field

The first detailed ethnography of the impact of this new technology through the exploration of the mobile phone's role in everyday life.

In 2001, India had 4 million cell phone subscribers. Ten years later, that number had exploded to more than 750 million. Over just a decade, the mobile phone was transformed from a rare and unwieldy instrument to a palm-sized, affordable staple, taken for granted by poor fishermen in Kerala and affluent entrepreneurs in Mumbai alike. The Great Indian Phone Book investigates the social revolution ignited by what may be the most significant communications device in history, one which has disrupted more people and relationships than the printing press, wristwatch, automobile, or railways, though it has qualities of all four. In this fast-paced study, Assa Doron and Robin Jeffrey explore the whole ecosystem of the cheap mobile phone. Blending journalistic immediacy with years of field-research experience in India, they portray the capitalists and bureaucrats who control the cellular infrastructure and wrestle over bandwidth rights, the marketers and technicians who bring mobile phones to the masses, and the often poor, village-bound users who adapt these addictive and sometimes troublesome devices to their daily lives. Examining the challenges cell phones pose to a hierarchy-bound country, the authors argue that in India, where caste and gender restrictions have defined power for generations, the disruptive potential of mobile phones is even greater than elsewhere. The Great Indian Phone Book is a rigorously researched, multidimensional tale of what can happen when a powerful and readily available technology is placed in the hands of a large, still predominantly poor population.

Neighboring cells are linked to each other by multimolecular complexes such as adherens junctions, desmosomes, and gap junctions. These complexes help maintain tissue integrity, act as barriers to permeability, reinforce cell polarity, and allow cells to communicate with each other. Written and edited by experts in the field, this collection from Cold Spring Harbor Perspectives in Biology reviews our understanding of the organization, regulation, and dynamics of cell-cell junctions and the roles they play in morphogenesis, tissue homeostasis, and disease. The contributors examine the assembly and structure of different cell-cell adhesion systems, the plasticity of cell-cell junctions (e.g., during cell migration), and how the junctions act as hubs to sense and transduce various mechanical and chemical signals. The authors also discuss the roles of cell-cell junctions in specific developmental and physiological processes, such as hearing, skeletal myogenesis, and neural circuit assembly, as well as in diseases such as cancer. This volume is therefore an indispensable reference for cell and developmental biologists, as well as anyone interested in understanding the roles of these complexes in human health and disease.

Comprehensive introduction to cell phone culture and theory.

New edition exploring the mechanical features of biological cells for advanced undergraduate and graduate students in physics and biomedical engineering.

Few modern innovations have spread quite so quickly as the cell phone. This technology has transformed communication throughout the world. Mobile telecommunications have had a dramatic effect in many regions, but perhaps nowhere more than for low-income populations in countries such as Jamaica, where in the last few years many people have moved from no phone to cell phone. This book reveals the central role of communication in helping low-income households cope with poverty. The book traces the impact of the cell phone from personal issues of loneliness and depression to the global concerns of the modern economy and the transnational family. As the technology of social networking, the cell phone has become central to establishing and maintaining relationships in areas from religion to love. The Cell Phone presents the first detailed ethnography of the impact of this new technology through the exploration of the cell phone's role in everyday lives.

Introduces cells, discussing their structure, life cycle, and what they can do.

An incessantly ringing cell phone in a quiet caf. A stranger at the next table who has had enough. And a dead man - with a lot of loose ends. So begins Dead Man's Cell Phone, a wildly imaginative new comedy by playwright Sarah Ruhl, recipient of a MacArthur ''Genius'' Grant and Pulitzer Prize finalist for her play The Clean House. A work about how we memorialize the dead - and how that remembering changes us - it is the odyssey of a woman forced to confront her own assumptions about morality, redemption, and the need to connect in a technologically obsessed world. Sarah Ruhl's plays have been produced at theaters around the country, including Lincoln Center Theater, the Goodman Theatre, Arena Stage, South Coast Repertory, Yale Repertory Theatre, Berkeley Repertory Theatre, among others, and internationally. She is the recipient of the Susan Smith Blackburn Prize (for The Clean House, 2004), the Helen Merrill Emerging Playwrights Award, and the Whiting Writers' Award. The Clean House was a Pulitzer Prize finalist in 2005. She is a member of 13P and New Dramatists.