Advances in itch research have elucidated differences between itch and pain but have also blurred the distinction between them. There is a long debate about how somatic sensations including touch, pain, itch, and temperature sensitivity are encoded by the nervous system. Research suggests that each sensory modality is processed along a fixed, direct-line communication system from the skin to the brain. Itch: Mechanisms and Treatment presents a timely update on all aspects of itch research and the clinical treatment of itch that accompanies many dermatological conditions including psoriasis, neuropathic itch, cutaneous t-cells lymphomas, and systemic diseases such as kidney and liver disease and cancer. Composed of contributions from distinguished researchers around the world, the book explores topics such as: Neuropathic itch Peripheral neuronal mechanism of itch The role of PAR-2 in neuroimmune communication and itch Mrgprs as itch receptors The role of interleukin-31 and oncostatin M in itch and neuroimmune communication Spinal coding of itch and pain Spinal microcircuits and the regulation of itch Examining new findings on cellular and molecular mechanisms, the book is a compendium of the most current research on itch, its prevalence in society, and the problems associated with treatment.

Based on careful analysis of burden of disease and the costs ofinterventions, this second edition of 'Disease Control Priorities in Developing Countries, 2nd edition' highlights achievable priorities; measures progresstoward providing efficient, equitable care; promotes cost-effectiveinterventions to targeted populations; and encourages integrated effortsto optimize health. Nearly 500 experts - scientists, epidemiologists, health economists,academicians, and public health practitioners - from around the worldcontributed to the data sources and methodologies, and identifiedchallenges and priorities, resulting in this integrated, comprehensivereference volume on the state of health in developing countries.

The podocyte is a key cell that forms the last barrier of the kidney filtration unit. One of the most exciting developments in the field of nephrology in the last decade has been the elucidation of its biology and its role in the pathophysiology of inherited and acquired glomerular disease, termed podocytopathy. In this publication, world-renowned experts summarize the most recent findings and advances in the field: they describe the unique biological features and injury mechanisms of the podocyte, novel techniques used in their study, and diagnosis and potential therapeutic approaches to glomerular diseases. Due to its broad scope, this publication is of great value not only for clinical nephrologists and researchers, but also for students, residents, fellows, and postdocs.

Known worldwide, chronic kidney disease (CKD) is a disease that affects up to 4% of the population with increasing figures also in the developing countries. Life expectancy of patients affected by CKD is shortened compared to the overall population, and only a minority of patients reach end-stage renal disease (ESRD) with the need for dialysis or renal transplantation; death overtakes dialysis. In the 13 chapters, this book sheds light on the different aspects related to pathophysiology and clinical aspects of CKD, providing interesting insights into not only inflammation and cardiovascular risk but also the interplay of hormones and the functional aspects of endothelial function. In addition, chapters dealing with genetic aspects of polycystic kidney disease and also the clinical handling of patients with CKD and peritoneal dialysis will be beneficial for the open-minded reader.

Comprehensive and up to date, the third edition of Diagnostic Pathology: Kidney Diseases, written by Robert B. Colvin, MD and Anthony Chang, MD, expertly covers all aspects of common and rare renal diseases and their variants. This easy-to-use, point-of-care reference offers a state-of-the-art, concise presentation of major pathological, clinical, pathophysiological, and genetic information for more than 240 diagnoses, making it an ideal resource for pathologists and nephrologists to improve knowledge and skills. Significantly revised information throughout ensures that you remain current with everything new regarding the pathology and pathogenesis of nonneoplastic kidney diseases. - New content with over 20 new chapters covering idiopathic non-lupus full-house nephropathy, hemophagocytic glomerulonephritis, cryofibrinogenemic glomerulopathy, metabolic syndrome and obesity-related glomerular disease, Whipple disease, systemic Castleman disease, nephropathies due to direct acting antivirals for HCV, checkpoint inhibitors, EGFR antagonists, illicit drugs and opioids, Tums glomerulopathy, vancomycin-induced cast nephropathy, transcript analysis of renal biopsies, new forms of amyloidosis, and mass spectroscopy - Updated and validated pathologic classifications systems reflect details on new genetic, therapeutic, and pathologic information, including IgA nephropathy, lupus nephritis, vasculitis, and transplant pathology - More than 3,300 outstanding, annotated images, including gross and microscopic pathology, a wide range of stains, and detailed medical illustrations, make this an invaluable diagnostic aid for every practicing pathologist, nephrologist, resident, or fellow - Time-saving reference features include consistently templated chapters, bulleted text, a variety of test data tables, key facts in each chapter, annotated images, and an extensive index - Internationally recognized authors, many new to this edition, provide fresh perspectives on multiple topics, with a particular emphasis on practical information that directly assists in making and supporting a diagnosis - Enhanced eBook version included with purchase, which allows you to access all of the text, figures, and references from the book on a variety of devices