Based on a series of regional meetings on university campuses with officials from the national security community and academic research institutions, this report identifies specific actions that should be taken to maintain a thriving scientific research environment in an era of heightened security concerns. Actions include maintaining the open exchange of scientific information, fostering a productive environment for international scholars in the U.S., reexamining federal definitions of sensitive but unclassified research, and reviewing policies on deemed export controls. The federal government should establish a standing entity, preferably a Science and Security Commission, that would review policies regarding the exchange of information and the participation of foreign-born scientists and students in research.

In its first Weapons of Mass Destruction (WMD) Case Study, the Center for the Study of Weapons of Mass Destruction (CSWMD) at the National Defense University examined President Richard M. Nixon's decision, on November 25, 1969, to terminate the U.S. offensive biological weapons program. This occasional paper seeks to explain why the Soviet government, at approximately the same time, decided to do essentially the opposite, namely, to establish a large biological warfare (BW) program that would be driven by newly discovered and powerful biotechnologies. By introducing the innovation of recombinant DNA technology - commonly referred to as genetic engineering - the Soviets were attempting to create bacterial and viral strains that were more useful for military purposes than were strains found in nature. In historical terms, the Soviet BW program had two so-called "generations," defined as distinct periods of time during which types of weapons were developed from earlier types. The first generation of the Soviet BW program commenced about 1928 and was based on naturally occurring pathogens that had caused devastating epidemics during World War I and the subsequent Russian Civil War. The second generation began approximately in 1972 when the decision was made at the highest political level to institute a research and development (R&D) system that utilized newly discovered techniques of genetic engineering to create novel or enhanced bacterial and viral strains that were better adapted for BW purposes than strains found in nature. President Boris Yeltsin ordered the cessation of the offensive BW program some months after the Soviet Union dissolved in December 1991 and in 1992 publically stated that it had conducted an offensive BW program in violation of the Biological and Toxin Weapons Convention. However, after Vladimir Putin was elected president, high-level Russian officials have lied about the Soviet BW program, stating that it was strictly a defensive program that had not broken international law. As is discussed later in this paper, elements of the Soviet offensive BW program continue in Russia and may provide the basis for a third-generation BW program supported by the current leadership. The first section of this paper describes the Soviet BW program's first generation, including its establishment, work plan and operations, and accomplishments. The second section focuses on "establishing the conditions" for the Soviet decision that was made sometime during 1969-1971 to establish and operate the second generation BW program. Conditions that are considered include the geopolitical challenges as perceived by the Soviet government, the decision making process for military acquisitions, and the inferior state of the biosciences in the Soviet Union at that time, which stimulated Soviet bioscientists to "play the military card" in order to introduce genetic engineering into the Union of Soviet Socialist Republics' (USSR's) bioscience establishment. The final section has two sub-sections. The first summarizes the key factors that drove Soviet decisionmaking in the early 1970s to institute a huge offensive BW program. The second informs readers that even before Vladimir Putin was elected president for the second time, he openly stated that new weapons were to be developed using high technologies including "genetics." Based on this promise, and considering the secrecy that still keeps the military biological institutes and anti-plague institutes closed to outsiders, the paper discusses the possibility that the Putin administration may institute a third generation BW program. The appendix consists of a short biography of the Soviet general Yefim Ivanovich Smirnov who was for many years in charge of the Soviet BW program.

In recent years much has happened to justify an examination of biological research in light of national security concerns. The destructive application of biotechnology research includes activities such as spreading common pathogens or transforming them into even more lethal forms. Policymakers and the scientific community at large must put forth a vigorous and immediate response to this challenge. This new book by the National Research Council recommends that the government expand existing regulations and rely on self-governance by scientists rather than adopt intrusive new policies. One key recommendation of the report is that the government should not attempt to regulate scientific publishing but should trust scientists and journals to screen their papers for security risks, a task some journals have already taken up. With biological information and tools widely distributed, regulating only U.S. researchers would have little effect. A new International Forum on Biosecurity should encourage the adoption of similar measures around the world. Seven types of risky studies would require approval by the Institutional Biosafety Committees that already oversee recombinant DNA research at some 400 U.S. institutions. These "experiments of concern" include making an infectious agent more lethal and rendering vaccines powerless.

This report surveys opportunities for future Army applications in biotechnology, including sensors, electronics and computers, materials, logistics, and medical therapeutics, by matching commercial trends and developments with enduring Army requirements. Several biotechnology areas are identified as important for the Army to exploit, either by direct funding of research or by indirect influence of commercial sources, to achieve significant gains in combat effectiveness before 2025.

Scientific advances over the past several decades have accelerated the ability to engineer existing organisms and to potentially create novel ones not found in nature. Synthetic biology, which collectively refers to concepts, approaches, and tools that enable the modification or creation of biological organisms, is being pursued overwhelmingly for beneficial purposes ranging from reducing the burden of disease to improving agricultural yields to remediating pollution. Although the contributions synthetic biology can make in these and other areas hold great promise, it is also possible to imagine malicious uses that could threaten U.S. citizens and military personnel. Making informed decisions about how to address such concerns requires a realistic assessment of the capabilities that could be misused. Biodefense in the Age of Synthetic Biology explores and envisions potential misuses of synthetic biology. This report develops a framework to guide an assessment of the security concerns related to advances in synthetic biology, assesses the levels of concern warranted for such advances, and identifies options that could help mitigate those concerns.

This is the first attempt to understand the full scope of the USSR’s offensive biological weapons research, from inception in the 1920s. Gorbachev tried to end the program, but the U.S. and U.K. never obtained clear evidence that he succeeded, raising the question whether the means for waging biological warfare could be present in Russia today.

The effort to understand and combat infectious diseases has, during the centuries, produced many key advances in science and medicine-including the development of vaccines, drugs, and other treatments. A subset of this research is conducted with agents that, like anthrax, not only pose a severe threat to the health of humans, plants, and animals but can also be used for ill-intended purposes. Such agents have been listed by the government as biological select agents and toxins. The 2001 anthrax letter attacks prompted the creation of new regulations aimed at increasing security for research with dangerous pathogens. The outcome of the anthrax letter investigation has raised concern about whether these measures are adequate. Responsible Research with Biological Select Agents and Toxins evaluates both the physical security of select agent laboratories and personnel reliability measures designed to ensure the trustworthiness of those with access to biological select agents and toxins. The book offers a set of guiding principles and recommended changes to minimize security risk and facilitate the productivity of research. The book recommends fostering a culture of trust and responsibility in the laboratory, engaging the community in oversight of the Select Agent Program, and enhancing the operation of the Select Agent Program.

Originating in the armed forces of the early 20th century, weapons based on chemical, biological or nuclear agents have become an everpresent threat that has not vanished after the end of the cold war. Since the technology to produce these agents is nowadays available to many countries and organizations, including those with terrorist aims, civil authorities across the world need to prepare against incidents involving these agents and train their personnel accordingly. As an introductory text on NBC CBRN weapons and agents, this book leads the reader from the scientific basics to the current threats and strategies to prepare against them. After an introductory part on the history of NBC CBRN weapons and their international control, the three classes of nuclear/radiological, biological, and chemical weapons are introduced, focusing on agents and delivery vehicles. Current methods for the rapid detection of NBC CBRN agents are introduced, and the principles of physical protection of humans and structures are explained. The final parts addresses more general issues of risk management, preparedness and response management, as the set of tools that authorities and civil services will be needed in a future CBRN scenario as well as the likely future scenarios that authorities and civil services will be faced with in the coming years. This book is a must-have for Health Officers, Public Health Agencies, and Military Authorities.

An arresting book about the incredible dangers and implications of genetic engineering harnessed to biological warfare.

This is the second edition of this publication which focuses on the public health aspects of the possible deliberate use of biological or chemical agents. Issues discussed include: the key principles for public health planning, risk assessment, hazard identification and evaluation, risk management strategies, and response planning as part of existing national emergency plans, disease surveillance and early warning systems, the national and international legal framework, and international sources of assistance. Technical annexes cover a range of issues including chemical agents, toxins, biological agents, principles of protection, precautions against the sabotage of drinking water, food and other products, information resources and the affiliation of WHO Member States to the international treaties on biological and chemical weapons.