"Cinchona revolutionized the art of medicine as profoundly as gunpowder had the art of war." -- Bernardino Ramazzini, Physician to the Duke of Modena, Opera omnia, medica, et physica, 1716 In the summer of 1623, ten cardinals and hundreds of their attendants died in Rome while electing a new pope. The Roman marsh fever that felled them was the scourge of the Mediterranean, northern Europe and even America. Malaria, now known as a disease of the tropics, badly weakened the Roman Empire. It killed thousands of British troops fighting Napoleon in 1809 and many soldiers on both sides of the American Civil War. It turned back travelers exploring West Africa in the nineteenth century and brought the building of the Panama Canal to a standstill. Even today, malaria kills someone every thirty seconds. For more than one thousand years, there was no cure for it. Pope Urban VIII, elected during the malarial summer of 1623, was determined that a cure should be found. He encouraged Jesuit priests establishing new missions in Asia and in South America to learn everything they could from the peoples they encountered. In Peru a young apothecarist named Agostino Salumbrino established an extensive network of pharmacies that kept the Jesuit missions in South America and Europe supplied with medicines. In 1631 Salumbrino dispatched a new miracle to Rome. The cure was quinine, an alkaloid made of the bitter red bark of the cinchona tree. Europe's Protestants, among them Oliver Cromwell, who suffered badly from malaria, feared that the new cure was nothing but a Popish poison. More than any previous medicine, though, quinine forced physicians to change their ideas about illness. Before long, it would change the face of Western medicine. Yet how was it that priests in the early seventeenth century–who did not know what malaria was or how it was transmitted–discovered that the bark of a tree that grew in the foothills of the Andes could cure a disease that occurred only on the other side of the ocean? Using fresh research from the Vatican and the Indian archives in Seville, as well as documents she discovered in Peru, award-winning author Fiammetta Rocco chronicles the ravages of the disease; the quest of the three Englishmen who smuggled cinchona seeds out of South America; the way in which quinine opened the door to Western imperial adventure in Asia, Africa and beyond; and how, even today, quinine grown in the eastern Congo still saves the lives of so many suffering from malaria.

This book examines how and why British imperial rule shaped scientific knowledge about malaria and its cures in nineteenth-century India. This title is also available as Open Access.

Admittedly, the world and the nature of forced migration have changed a great deal over the last two decades. The relevance of data accumulated during that time period can now be called into question. The roundtable and the Program on Forced Migration at the Mailman School of Public Health of Columbia University have commissioned a series of epidemiological reviews on priority public health problems for forced migrants that will update the state of knowledge. Malaria Control During Mass Population Movements and Natural Disasters- the first in the series, provides a basic overview of the state of knowledge of epidemiology of malaria and public health interventions and practices for controlling the disease in situations involving forced migration and conflict.

Literally Italian for "bad air," malaria once plagued Rome, tropical trade routes and colonial ventures into India and South America and the disease has no known antidote aside from the therapeutic effects of the "miraculous" quinine. This first book from journalist Honigsbaum is a rousing history of the search for febrifuge or, more specifically, the rare red cinchona tree, the bark from which quinine is derived.

For more than 50 years, low-cost antimalarial drugs silently saved millions of lives and cured billions of debilitating infections. Today, however, these drugs no longer work against the deadliest form of malaria that exists throughout the world. Malaria deaths in sub-Saharan Africaâ€"currently just over one million per yearâ€"are rising because of increased resistance to the old, inexpensive drugs. Although effective new drugs called "artemisinins" are available, they are unaffordable for the majority of the affected population, even at a cost of one dollar per course. Saving Lives, Buying Time: Economics of Malaria Drugs in an Age of Resistance examines the history of malaria treatments, provides an overview of the current drug crisis, and offers recommendations on maximizing access to and effectiveness of antimalarial drugs. The book finds that most people in endemic countries will not have access to currently effective combination treatments, which should include an artemisinin, without financing from the global community. Without funding for effective treatment, malaria mortality could double over the next 10 to 20 years and transmission will intensify.

Written by the foremost authority in the field, this volume is a comprehensive review of the multifaceted phenomenon of hepatotoxicity. Dr. Zimmerman examines the interface between chemicals and the liver; the latest research in experimental hepatotoxicology; the hepatotoxic risks of household, industrial, and environmental chemicals; and the adverse effects of drugs on the liver. This thoroughly revised, updated Second Edition features a greatly expanded section on the wide variety of drugs that can cause liver injury. For quick reference, an appendix lists these medications and their associated hepatic injuries. Also included are in-depth discussions of drug metabolism and factors affecting susceptibility to liver injury.

Among the many who serve in the United States Armed Forces and who are deployed to distant locations around the world, myriad health threats are encountered. In addition to those associated with the disruption of their home life and potential for combat, they may face distinctive disease threats that are specific to the locations to which they are deployed. U.S. forces have been deployed many times over the years to areas in which malaria is endemic, including in parts of Afghanistan and Iraq. Department of Defense (DoD) policy requires that antimalarial drugs be issued and regimens adhered to for deployments to malaria-endemic areas. Policies directing which should be used as first and as second-line agents have evolved over time based on new data regarding adverse events or precautions for specific underlying health conditions, areas of deployment, and other operational factors At the request of the Veterans Administration, Assessment of Long-Term Health Effects of Antimalarial Drugs When Used for Prophylaxis assesses the scientific evidence regarding the potential for long-term health effects resulting from the use of antimalarial drugs that were approved by FDA or used by U.S. service members for malaria prophylaxis, with a focus on mefloquine, tafenoquine, and other antimalarial drugs that have been used by DoD in the past 25 years. This report offers conclusions based on available evidence regarding associations of persistent or latent adverse events.

Investigates price rises in quinidine and quinine in relationship to market factors and alleged attempts of a Netherlands cartel and West German companies to control world supply and prices.