Healthcare decision makers in search of reliable information that compares health interventions increasingly turn to systematic reviews for the best summary of the evidence. Systematic reviews identify, select, assess, and synthesize the findings of similar but separate studies, and can help clarify what is known and not known about the potential benefits and harms of drugs, devices, and other healthcare services. Systematic reviews can be helpful for clinicians who want to integrate research findings into their daily practices, for patients to make well-informed choices about their own care, for professional medical societies and other organizations that develop clinical practice guidelines. Too often systematic reviews are of uncertain or poor quality. There are no universally accepted standards for developing systematic reviews leading to variability in how conflicts of interest and biases are handled, how evidence is appraised, and the overall scientific rigor of the process. In Finding What Works in Health Care the Institute of Medicine (IOM) recommends 21 standards for developing high-quality systematic reviews of comparative effectiveness research. The standards address the entire systematic review process from the initial steps of formulating the topic and building the review team to producing a detailed final report that synthesizes what the evidence shows and where knowledge gaps remain. Finding What Works in Health Care also proposes a framework for improving the quality of the science underpinning systematic reviews. This book will serve as a vital resource for both sponsors and producers of systematic reviews of comparative effectiveness research.

Hydrogen has gained global recognition as a crucial energy resource, holding immense potential to offer clean, efficient, cost-effective, and environmentally friendly energy solutions. Through water electrolysis powered by green electricity, the production of decarbonized “green hydrogen” is achievable. Hydrogen technology emerges as a key pathway for realizing the global objective of “carbon neutrality.” Among various water electrolysis technologies, proton exchange membrane water electrolysis (PEMWE) stands out as exceptionally promising. It boasts high energy density, elevated electrolysis efficiency, and the capacity for high output pressure, making it a frontrunner in the quest for sustainable hydrogen production. The Application of Proton Exchange Membrane Water Electrolysis delves into the challenges and trends ahead of PEMWE—from fundamental research to practical application—and briefly describes its relative characteristics, key components, and future targets. The cost-effectiveness of PEMWE is illustrated and the report explores the potential for deeper integration into various industries, such as renewable energy consumption and hydrogen for industrial purposes. It further points the current trends, concluding with a series of recommendations for consideration by government, industry stakeholders, and researchers. Click here to access the full SAE EDGETM Research Report portfolio. https://doi.org/10.4271/EPR2024014