* The most up-to-date and comprehensive coverage of the relationship of brain function and neuroactive chemicals * Authors are world-known leaders in the field * Molecular Neuropharmacology is the hot topic in medicine

Now in its third edition, Principles of Pharmacology presents content in a conceptual framework that maximizes understanding and retention and minimizes rote memorization. It takes students "beyond the disease" and deep into physiologic, biochemical, and pathophysiologic systems where drugs activate or inhibit these systems by interacting with molecular and cellular targets. This unique approach ensures understanding of the mechanisms of drug actions on the body, and ultimately, in treating the human patient. Ideal for introductory pharmacology courses that emphasize critical thinking, molecular understanding, systems-based integration, and clinical preparation, the text: Features chapter-opening clinical cases and questions to establish a context for the discussion and the answers that follow Presents signature drug summary tables, updated and organized by mechanism of action, with information on clinical applications, adverse effects, contraindications, and therapeutic considerations Incorporates NEW full-color illustrations throughout, suiting the needs of visual learners and more effectively presenting concepts covered in the narrative Integrates timely content, including recently approved drugs as well as current research on drug mechanisms of action Delivers course and review material appropriate for students through a uniquely collaborative authorship consisting of medical students, residents, and faculty

This primary textbook for a first course in pharmacology offers an integrated, systems-based, and mechanism-based approach to understanding drug therapy. Each chapter focuses on a target organ system, begins with a clinical case, and incorporates cell biology, biochemistry, physiology, and pathophysiology to explain how and why different drug classes are effective for diseases in that organ system. Over 400 two-color illustrations show molecular, cellular, biochemical, and pathophysiologic processes underlying diseases and depict targets of drug therapy. Each Second Edition chapter includes a drug summary table presenting mechanism, clinical applications, adverse effects, contraindications, and therapeutic considerations. New chapters explain how drugs produce adverse effects and describe the life cycle of drug development. The fully searchable online text and an image bank are available on thePoint.

This comprehensive survey of neuropsychopharmacology is unique in its breadth of coverage, from molecular to behavioural pharmacology, and from basic animal studies of drug action to clinical applications. Lavish illustrations and concise chapter summaries reinforce key concepts, while extensive references point the way to further study. The book is intended for advanced undergraduate, graduate and medical students, and neuroscientists seeking current information on psychoactive drugs.

With a focus on functional relationships between drugs and their targets, this book covers basic and general pharmacology, from a cellular and molecular perspective, with particular attention to the mechanisms of drug action – the fundamental basis for proper clinical use- without neglecting clinical application, toxicology and pharmacokinetics. • Covers cell and molecular pharmacology, bringing together current research on regulation of drug targets, at a level appropriate for advanced undergrad and graduate students • Discusses the relevance of pharmacokinetics and drug development for the clinical application of drugs • Presents material from the perspective of drug targets and interaction, the theoretical basis of drug action analysis, and drug properties • Focuses on structure-function relationships of drug targets – informing about their biochemical and physiologic functions and experimental and clinical pathways for drug discovery and development • Has a companion website that offers a host of resources: short additional chapters about methodology, topics at the forefront of research, and all figures and tables from the book

This new edition of Principles of Drug Action is a complete revision of a very-successful graduate-level pharmacology text previously authored by Avram Goldstein, Lewis Aronow and Sumner Kalman. Features: * Thorough survey of the many advances since the previous edition, plus a substantially expanded review of immunopharmacology * Covers basic principles of how drugs affect biological organisms * Explains the principles which govern drug action, absorption, metabolism, and distribution * Provides a solid grounding in modern biochemistry, molecular biology and genetics * Organized around systematic principles rather than drug families or drug effects

Principles and Practice of Neuropsychopharmacology: A Clinical Reference for Residents, Physicians, and Biomedical Scientists is a concise yet comprehensive book that discusses the drugs used in the treatment of neurological and psychiatric diseases from the perspective of practicing clinicians. There is a considerable overlap between these two specialties as neurologists often use the medicines used by psychiatrists and vice versa. This book addresses the merger of topics of mutual interest for them in a single volume of contemporary pharmacology. It provides detailed coverage of pharmacotherapy of neurological and psychiatric disorders in general practice. The content has been made more accessible with the judicious use of tables and figures, case examples, and details of neurochemical alterations. The book is useful for both beginners and advanced readers as it details clinical practices followed in dealing with psychiatric patients in developing nations like India to enhance practice-oriented learning and provides evidence-based guidelines from world's leading medical bodies. Key Features: Lucid description of pharmacokinetic principles and pharmacodynamics of neuropharmacological agents Thoroughly covers currently used medications in treating a spectrum of diseases of the brain and nervous system Separate chapters dedicated for drugs used for treating depression, mania, anxiety, and insomnia

Celebrating 100 years of HEP, this volume will discuss key pharmacological discoveries and concepts of the past 100 years. These discoveries have dramatically changed the medical treatment paradigms of many diseases and these concepts have and will continue to shape discovery of new medicinies. Newly evolving technologies will similarly be discussed as they will shape the future of the pharmacology and, accordingly, medical therapy.

This volume gives an overview of new insights to alcohol pharmacology using DREADDs (Designer Receptors and Unraveling the Neuropharmacology of Alcohol). It examines which pharmacological principles should be applied to understanding DREADDs taking into account some very current research. Additionally, this book covers important topics under the heading of “experimental pharmacology” and alcohol.