The first edition of this book achieved considerable success due to its ease of use and practical approach, and to the clear writing style of the authors. The preparation of organic compounds is still central to many disciplines, from the most applied to the highly academic and, more tan ever is not limited to chemists. With an emphasis on the most up-to-date techniques commonly used in organic syntheses, this book draws on the extensive experience of the authors and their association with some of the world's mleading laboratories of synthetic organic chemistry. In this new edition, all the figures have been re-drawn to bring them up to the highest possible standard, and the text has been revised to bring it up to date. Written primarily for postgraduate, advanced undergraduate and industrial organic chemists, particularly those involved in pharmaceutical, agrochemical and other areas of fine chemical research, the book is also a source of reference for biochemists, biologists, genetic engineers, material scientists and polymer researchers.

One of the very best things about organic chemistry is actually doing experimental work at the beneh. This applies not only at the profes sionallevel but also from the earliest stages of apprenticeship to the craft as a student. The fascination sterns from the nature of the sub ject itself, with its vast array of different types of reaction and its al most infinite variety of different chemical compounds. Each reaction and each new compound pose their own particular problems to chal lenge the skill and ingenuity of the chemist, whether working in a first-year teaching la bora tory or at the frontiers of research. This book is intended to provide basic guidance in the essential experimental techniques used in a typical undergraduate course. It gives concise coverage of the range of practical skills required, from first-year level when students may have no previous experience, up to final-year level when students are usually involved in more complex and dem an ding experimental work in supervised research projects. Our objective was to produce a handbook of techniques that could be used with a variety of practical courses throughout a student's whole period of study. Those who run practical courses generally have strong feelings about what particular experiments or exercises are appropriate for their own students, and it is rare that a book of experiments suitable for one department is acceptable to another.

A hands-on guide to assist in the planning and execution of synthetic reactions in the laboratory Despite the maturity of organic chemistry, it can still be very challenging to identify optimal methods for synthetic transformations that perform as well in real-world manufacturing processes as they do in the laboratory. This detailed and accessible guide attempts to address this vexing issue and deliver proven methodologies practicing synthetic chemists will find valuable for identifying reaction conditions that work reliably over the broadest possible range of substrates. Practical Synthetic Organic Chemistry: Provides a practical guide to strategically planning and executing chemical syntheses for the bench chemist in industry Discusses information that is not common knowledge beyond the boundaries of process chemistry groups, such as the synthetic routes of selected contemporary pharmaceutical drugs and practical solvents, as well as green chemistry concepts Highlights key reactions, including substitutions, additions, eliminations, rearrangements, oxidations, and reductions Addresses basic principles, mechanisms, advantages and disadvantages of the methodology, and techniques for achieving laboratory success Incorporating such an extraordinary wealth of information on organic chemistry and its related fields into one complete volume distinguishes Practical Synthetic Organic Chemistry as an incomparable desktop reference for professionals and an invaluable study aid for students.

This book is a hands-on guide for the organic chemist. Focusing on the most reliable and useful reactions, the chapter authors provide the information necessary for a chemist to strategically plan a synthesis, as well as repeat the procedures in the laboratory. Consolidates all the key advances/concepts in one book, covering the most important reactions in organic chemistry, including substitutions, additions, eliminations, rearrangements, oxidations, reductions Highlights the most important reactions, addressing basic principles, advantages/disadvantages of the methodology, mechanism, and techniques for achieving laboratory success Features new content on recent advances in CH activation, photoredox and electrochemistry, continuous chemistry, and application of biocatalysis in synthesis Revamps chapters to include new and additional examples of chemistry that have been demonstrated at a practical scale

This book describes the use of NMR spectroscopy for dealing with problems of small organic molecule structural elucidation. It features a significant amount of vital chemical shift and coupling information but more importantly, it presents sound principles for the selection of the techniques relevant to the solving of particular types of problem, whilst stressing the importance of extracting the maximum available information from the simple 1-D proton experiment and of using this to plan subsequent experiments. Proton NMR is covered in detail, with a description of the fundamentals of the technique, the instrumentation and the data that it provides before going on to discuss optimal solvent selection and sample preparation. This is followed by a detailed study of each of the important classes of protons, breaking the spectrum up into regions (exchangeables, aromatics, heterocyclics, alkenes etc.). This is followed by consideration of the phenomena that we know can leave chemists struggling; chiral centres, restricted rotation, anisotropy, accidental equivalence, non-first-order spectra etc. Having explained the potential pitfalls that await the unwary, the book then goes on to devote chapters to the chemical techniques and the most useful instrumental ones that can be employed to combat them. A discussion is then presented on carbon-13 NMR, detailing its pros and cons and showing how it can be used in conjunction with proton NMR via the pivotal 2-D techniques (HSQC and HMBC) to yield vital structural information. Some of the more specialist techniques available are then discussed, i.e. flow NMR, solvent suppression, Magic Angle Spinning, etc. Other important nuclei are then discussed and useful data supplied. This is followed by a discussion of the neglected use of NMR as a tool for quantification and new techniques for this explained. The book then considers the safety aspects of NMR spectroscopy, reviewing NMR software for spectral prediction and data handling and concludes with a set of worked Q&As.

Success in an experimental science such as chemistry depends on good laboratory practice, a knowledge of basic techniques, and the intelligent and careful handling of chemicals. Practical Organic Synthesis is a concise, useful guide to good laboratory practice in the organic chemistry lab with hints and tips on successful organic synthesis. Topics covered include: safety in the laboratory environmentally responsible handling of chemicals and solvents crystallisation distillation chromatographic methods extraction and work-up structure determination by spectroscopic methods searching the chemical literature laboratory notebooks writing a report hints on the synthesis of organic compounds disposal and destruction of dangerous materials drying and purifying solvents Practical Organic Synthesis is based on a successful course in basic organic chemistry laboratory practice which has run for several years at the ETH, Zurich and the University of Berne, and its course book Grundoperationen, now in its sixth edition. Condensing over 30 years of the authors’ organic laboratory teaching experience into one easy-to-read volume, Practical Organic Synthesis is an essential guide for those new to the organic chemistry laboratory, and a handy benchtop guide for practising organic chemists.

This expansive and practical textbook contains organic chemistry experiments for teaching in the laboratory at the undergraduate level covering a range of functional group transformations and key organic reactions.The editorial team have collected contributions from around the world and standardized them for publication. Each experiment will explore a modern chemistry scenario, such as: sustainable chemistry; application in the pharmaceutical industry; catalysis and material sciences, to name a few. All the experiments will be complemented with a set of questions to challenge the students and a section for the instructors, concerning the results obtained and advice on getting the best outcome from the experiment. A section covering practical aspects with tips and advice for the instructors, together with the results obtained in the laboratory by students, has been compiled for each experiment. Targeted at professors and lecturers in chemistry, this useful text will provide up to date experiments putting the science into context for the students.

Organicum: Practical Handbook of Organic Chemistry focuses on the theory, laboratory practice, and aspects of technical use related to organic chemistry. This book discusses the standard apparatus for organic reactions, heating of inflammable liquids, performance of a simple distillation, and partition chromatography in separating columns. The time factor in organic chemical reactions, distribution of the electron density in organic molecules, and synthesis of ethers from alkoxides or phenoxides are also elaborated. This text likewise covers the mechanism of electrophilic aromatic substitution, quinones from aromatic hydrocarbons, and reduction of carbonyl compounds by means of complex hydrides. Other topics include the reaction with ammoniacal solution of a silver salt, preparation of the dimedone derivatives, and saturated aliphatic hydrocarbons. This publication is suitable for chemists and researchers conducting work in organic chemistry.

Diagnose and Troubleshoot Problems in Chemical Process Equipment with This Updated Classic! Chemical engineers and plant operators can rely on the Third Edition of A Working Guide to Process Equipment for the latest diagnostic tips, practical examples, and detailed illustrations for pinpointing trouble and correcting problems in chemical process equipment. This updated classic contains new chapters on Control Valves, Cooling Towers, Waste Heat Boilers, Catalytic Effects, Fundamental Concepts of Process Equipment, and Process Safety. Filled with worked-out calculations, the book examines everything from trays, reboilers, instruments, air coolers, and steam turbines...to fired heaters, refrigeration systems, centrifugal pumps, separators, and compressors. The authors simplify complex issues and explain the technical issues needed to solve all kinds of equipment problems. Comprehensive and clear, the Third Edition of A Working Guide to Process Equipment features: Guidance on diagnosing and troubleshooting process equipment problems Explanations of how theory applies to real-world equipment operations Many useful tips, examples, illustrations, and worked-out calculations New to this edition: Control Valves, Cooling Towers, Waste Heat Boilers, Catalytic Effects, and Process Safety Inside this Renowned Guide to Solving Process Equipment Problems • Trays • Tower Pressure • Distillation Towers • Reboilers • Instruments • Packed Towers • Steam and Condensate Systems • Bubble Point and Dew Point • Steam Strippers • Draw-Off Nozzle Hydraulics • Pumparounds and Tower Heat Flows • Condensers and Tower Pressure Control • Air Coolers • Deaerators and Steam Systems • Vacuum Systems • Steam Turbines • Surface Condensers • Shell-and-Tube Heat Exchangers • Fire Heaters • Refrigeration Systems • Centrifugal Pumps • Separators • Compressors • Safety • Corrosion • Fluid Flow • Computer Modeling and Control • Field Troubleshooting Process Problems