This collection of pediatric clinical cases focus on multiple sclerosis, neuromyelitis optica, acute disseminated encephalomyelitis and mimics. Dedicated sections on diseases affecting the brain, brainstem, spinal cord and the optic nerve feature chapters that include the diagnostic work up, therapeutic management and case outcome. Typical and atypical presentations of various pediatric demyelinating diseases also emphasize therapy response and those that breakthrough on treatment. Filling a critical gap in the literature on inflammatory disorders of the central nervous system, all those that treat patients with these rare and challenging disorders will find this book extremely helpful for their daily clinical practice.

This issue reviews the state of the art in pediatric demyelinating diseases. Articles cover topics on childhood transverse myelitis, neuromyelitis optica, multiple sclerosis, acute demyelinating encephalopathy, and more.

This issue reviews the state of the art in pediatric demyelinating diseases. Articles cover topics on childhood transverse myelitis, neuromyelitis optica, multiple sclerosis, acute demyelinating encephalopathy, and more.

Although multiple sclerosis and other disorders of myelin formation and repair are most commonly associated with adults, they can also occur in infants, children and adolescents. Up to 5 percent of those with MS experience symptoms before the age of 18, and the number of cases diagnosed is rising. There is a lack of awareness about these diseases in childhood, however, even amongst pediatric neurologists and MS specialists. Demyelinating Disorders of the Central Nervous System in Childhood provides comprehensive coverage of these diseases, highlighting throughout the differences between management in childhood and in adults. With sections dedicated to the diagnosis, course, treatment and biology of pediatric MS, detailed chapters on other childhood demyelinating diseases, including acute disseminated encephomyelitis, optic neuritis, acute complete transverse myelitis and neuromyelitis optica, are also provided. Essential reading for pediatric neurologists and MS specialists, this book will also be valuable reading for adult neurologists and pediatricians.

This open access book offers an essential overview of brain, head and neck, and spine imaging. Over the last few years, there have been considerable advances in this area, driven by both clinical and technological developments. Written by leading international experts and teachers, the chapters are disease-oriented and cover all relevant imaging modalities, with a focus on magnetic resonance imaging and computed tomography. The book also includes a synopsis of pediatric imaging. IDKD books are rewritten (not merely updated) every four years, which means they offer a comprehensive review of the state-of-the-art in imaging. The book is clearly structured and features learning objectives, abstracts, subheadings, tables and take-home points, supported by design elements to help readers navigate the text. It will particularly appeal to general radiologists, radiology residents, and interventional radiologists who want to update their diagnostic expertise, as well as clinicians from other specialties who are interested in imaging for their patient care.

Provides comprehensive coverage of pediatric multiple sclerosis and similar conditions, highlighting differential diagnosis, investigation and management.

Chapter 1. Approach to Neurological Assessment in Children Chapter 2. Approach to Localization of Neurological Disorders Chapter 3. Approach to Congenital Malformation of Brain Chapter 4. Approach to Abnormal Head: Size and Shape Chapter 5. Approach to Developmental Delay in Children Chapter 6. Approach to Intellectual Disability and Specific Learning Disorder Chapter 7. Approach to Autism Chapter 8. Approach to Inborn Errors of Metabolism in Neonate, Infant, and Children Chapter 9. Approach to Neuronal Migration Disorders Chapter 10. Approach to Acute Febrile Chapter 11. Approach to Acute Encephalitis (Indian Scenario) Chapter 12. Approach to Childhood Neurotuberculosis in Children Chapter 13. Approach to Cerebral Malaria Chapter 14. Approach to Neurocysticercosis in Children Chapter 15. Approach to Fungal Infections of Central Nervous System Chapter 16. Approach to Altered Sensorium Chapter 17. Approach to Acute Stroke Syndrome Chapter 18. Approach to Febrile Seizures and Fever-related Epilepsies Chapter 19. Approach to a Child with Epilepsy Chapter 20. Approach to Self-limited Focal Epilepsies of Childhood Chapter 21. Approach to Intractable Seizures Chapter 22. Approach to Seizures Imitator and Seizure Mimics Chapter 23. Approach to Dizziness and Vertigo in Children Chapter 24. Approach to Neonatal Seizures Chapter 25. Approach to Management of Status Epilepticus Chapter 26. Current Guidelines for Diagnosis and Management of Childhood Epilepsy Chapter 27. Approach to Neurological Emergencies in Children Chapter 28. Approach to Child with Cerebral Palsy Chapter 29. Approach to Early Intervention Therapy in Cerebral Palsy Chapter 30. Approach to Neurodegenerative Disorders Chapter 31. Approach to Demyelinating Disorders of Central Nervous System Chapter 32. Approach to Movement Disorders in Children Chapter 33. Approach to Opsoclonus Myoclonus Syndrome Chapter 34. Approach to a Child with Ataxia Chapter 35. Approach to Neuromuscular Diseases Chapter 36. Approach to Child with Acute Flaccid Paralysis Chapter 37. Approach to Paraplegia Chapter 38. Approach to Floppy Infant Chapter 39. Approach to a Child with Myopathy and Myositis Chapter 40. Approach to Headache in Children Chapter 41. Approach to Neurocutaneous Syndrome Chapter 42. Approach to Nutritional Disorders of Nervous System Chapter 43. Approach to Rabies Chapter 44. Approach to Neurotoxic Snake Envenomation Chapter 45. Fundus Examination in Children Chapter 46. Approach to Cerebrospinal Fluid Interpretation in Children Chapter 47. Approach to Neurophysiological Investigations Chapter 48. Approach to Basics of MRI and CT Scan Drugs Appendix Index

Magnetic resonance imaging (MRI) is now considered the imaging modality of choice for the majority of disorders affecting the central nervous system. This is particularly true for gray and white matter disorders, thanks to the superb soft tis sue contrast in MRI which allows gray matter, unmyelinated, and myelinated white matter to be distinguished and their respective disorders identified. The pre sent book is devoted to the disorders of myelin and myelination. A growing amount of detailed in vivo information about myelin, myelination, and myelin dis orders has been derived both from MRI and from MR spectroscopy (MRS). This prompted us to review the clinical, laboratory, biochemical, and pathological data on this subject in order to integrate all available information and to provide im proved insights into normal and disordered myelin and myelination. We will show how the synthesis of all available information contributes to the interpretation of MR images. After a brief historical review about the increasing knowledge on myelin and my elin disorders, we propose a new classification of myelin disorders based on the subcellular localization of the enzymatic defects as far as the inborn errors of me tabolism are concerned. This classification serves as a guide throughout the book. All items of the classification will be discussed and, whenever relevant and possi ble, be illustrated by MR images.

This book provides cutting-edge information on the epidemiology, etiopathogenesis, clinical manifestations, diagnostic procedures and treatment approaches for the main white matter (WM) disorders of the central nervous system (CNS). WM lesions are associated with many neurological conditions, and with aging. The diagnostic work-up of neurological diseases characterized by the presence of these lesions has changed dramatically over the past few years. This is mainly due on the one hand to the discovery of specific pathogenetic factors in some of these conditions, and on the order to the optimized use of diagnostic tools. All of this has resulted in new diagnostic algorithms, and in the identification of new neurological conditions. The book offers neurologists essential guidance in the diagnosis and treatment of the most frequent WM conditions, promoting their correct and cost-saving diagnosis and management. By integrating neurological, laboratory and imaging concepts with the demands of accurate diagnosis, this reference guide provides a state-of-the-art overview of the current state of knowledge on these conditions, as well as practical guidelines for their diagnosis and treatment.