N-of-1 trials, a type of individualized randomized controlled trial, are relevant to almost every discipline in medicine and psychology. They can tell the clinician with precision whether a treatment works in that individual, which distinguishes from the information available from most other trial designs. They have the potential to revolutionize the way clinical medicine is practiced. Whether you are a busy clinician, a researcher or a student, this book provides everything you need to know about N-of-1 trials. Written and edited by some of the world’s leading experts on N-of-1 trials, the book presents state of the art knowledge about N-of-1 trials, with chapters on ethics, statistics, health economics, design, analysis and reporting, and more. Full of examples and well illustrated, it is a comprehensive compendium of issues surrounding the design, conduct, interpretation and implementation of N-of-1 trials in a health system.

Twenty-five years ago my doctors had no cure for my cancer. So I went on a quest to find my own treatment. This is my story... Glenn Sabin was diagnosed with "incurable" leukemia (CLL). He embarked on a journey researching lifestyle changes, and conducted a personal experiment, chronicled through Harvard, now part of the medical literature.

The NIV is the world's best-selling modern translation, with over 150 million copies in print since its first full publication in 1978. This highly accurate and smooth-reading version of the Bible in modern English has the largest library of printed and electronic support material of any modern translation.

Cultural Writing. Literary Criticism. The two discussions in WHAT WE SHOULD HAVE KNOWN took place at the offices of n+1 in the summer of 2007. Eleven n+1 editors and contributors--including Caleb Crain, Meghan Falvey, Mark Greif, and Ilya Bernstein--met to talk frankly about regrets they have (or don't have) about college--what they wish they had read or had not read, listened to or not listened to, thought or not thought, been or not been. The idea for the discussions was prompted by a desire to give college students a directed guide, of some sort, to the world of literature, philosophy, and thought that they might not otherwise receive from the current highly specialized university environment. They were also an attempt to answer the "canon"-based approach to college study in two ways: by identifying canonical books produced by our contemporaries or near-contemporaries--something conservative writers have always refused to do--and, second, by articulating a better reason to read the best books ever written than that they authorize and underwrite a system of brutal economic competition and inequality.

“Before I knew that I was Jewish or a girl I knew that I was a member of the working class.” So begins Vivian Gornick’s exploration of how the world of socialists, communists, and progressives in the 1940s and 1950s created a rich, diverse world where ordinary men and women felt their lives connected to a larger human project. Now back in print after its initial publication in 1977 and with a new introduction by the author, The Romance of American Communism is a landmark work of new journalism, profiling American Communist Party members and fellow travelers as they joined the Party, lived within its orbit, and left in disillusionment and disappointment as Stalin’s crimes became public. From the immigrant Jewish enclaves of the Bronx and Brooklyn and the docks of Puget Sound to the mining towns of Kentucky and the suburbs of Cleveland, over a million Americans found a sense of belonging and an expanded sense of self through collective struggle. They also found social isolation, blacklisting, imprisonment, and shattered hopes. This is their story--an indisputably American story.

An inside look at the politics of book reviewing, from the assignment and writing of reviews to why critics think we should listen to what they have to say Taking readers behind the scenes in the world of fiction reviewing, Inside the Critics’ Circle explores the ways critics evaluate books despite the inherent subjectivity involved and the uncertainties of reviewing when seemingly anyone can be a reviewer. Drawing on interviews with critics from such venues as the New York Times, Los Angeles Times, and Washington Post, Phillipa Chong delves into the complexities of the review-writing process, including the considerations, values, and cultural and personal anxieties that shape what critics do. Chong explores how critics are paired with review assignments, why they accept these time-consuming projects, how they view their own qualifications for reviewing certain books, and the criteria they employ when making literary judgments. She discovers that while their readers are of concern to reviewers, they are especially worried about authors on the receiving end of reviews. As these are most likely peers who will be returning similar favors in the future, critics’ fears and frustrations factor into their willingness or reluctance to write negative reviews. At a time when traditional review opportunities are dwindling while other forms of reviewing thrive, book reviewing as a professional practice is being brought into question. Inside the Critics’ Circle offers readers a revealing look into critics’ responses to these massive transitions and how, through their efforts, literary values get made.

"A follow-up to n+1's 2007 pamplet What we should have known, No regrets talks to twelve writers, editors, activists, academics, and artists about life and reading in their early twenties"--from page [4] of cover.

Who's going to provide for your future? There's a crisis looming in pensions. Investing in property is time-consuming and risky. Savings accounts yield very little return. If you're not careful, you could be looking at a very uncomfortable retirement. But surely the alternative - investing in the stock market - is risky, complicated and best left to the professionals? Phil Town doesn't think so. He made a fortune, and in Rule #1 he'll show you how he did it. Rule #1: - Sets out the five key numbers that really count when you're buying stocks and shares - Explains how to use new Internet tools to simplify research - Shows how to exploit the advantages of being an individual investor - Demonstrates how to pay fifty pence for every pound's worth of business This simple and straightforward method will guide you to 15% or better annual returns - in only 15 minutes a week. It's money in the bank!