This book provides both in-depth background and up-to-date information in this area. The chapters are organized by general themes and principles, written by experts who illustrate topics with current findings. Topics covered include: - the role of ions and hydration in protein-nucleic acid interactions - transcription factors and combinatorial specificity - indirect readout of DNA sequence - single-stranded nucleic acid binding proteins - nucleic acid junctions and proteins, - RNA protein recognition - recognition of DNA damage. It will be a key reference for both advanced students and established scientists wishing to broaden their horizons.

This is the second revised and extended edition of the successful book on the algebraic structure of the Stone-Čech compactification of a discrete semigroup and its combinatorial applications, primarily in the field known as Ramsey Theory. There has been very active research in the subject dealt with by the book in the 12 years which is now included in this edition. This book is a self-contained exposition of the theory of compact right semigroups for discrete semigroups and the algebraic properties of these objects. The methods applied in the book constitute a mosaic of infinite combinatorics, algebra, and topology. The reader will find numerous combinatorial applications of the theory, including the central sets theorem, partition regularity of matrices, multidimensional Ramsey theory, and many more.

For junior/senior undergraduates taking probability and statistics as applied to engineering, science, or computer science. This classic text provides a rigorous introduction to basic probability theory and statistical inference, with a unique balance between theory and methodology. Interesting, relevant applications use real data from actual studies, showing how the concepts and methods can be used to solve problems in the field. This revision focuses on improved clarity and deeper understanding. This latest edition is also available in as an enhanced Pearson eText. This exciting new version features an embedded version of StatCrunch, allowing students to analyze data sets while reading the book. Also available with MyStatLab MyStatLab(tm) is an online homework, tutorial, and assessment program designed to work with this text to engage students and improve results. Within its structured environment, students practice what they learn, test their understanding, and pursue a personalized study plan that helps them absorb course material and understand difficult concepts. Note: You are purchasing a standalone product; MyLab(tm) & Mastering(tm) does not come packaged with this content. Students, if interested in purchasing this title with MyLab & Mastering, ask your instructor for the correct package ISBN and Course ID. Instructors, contact your Pearson representative for more information. If you would like to purchase both the physical text and MyLab & Mastering, search for: 0134468910 / 9780134468914 Probability & Statistics for Engineers & Scientists, MyStatLab Update with MyStatLab plus Pearson eText -- Access Card Package 9/e Package consists of: 0134115856 / 9780134115856 Probability & Statistics for Engineers & Scientists, MyStatLab Update 0321847997 / 9780321847997 My StatLab Glue-in Access Card 032184839X / 9780321848390 MyStatLab Inside Sticker for Glue-In Packages

This book gives a general outlook on homotopy theory; fundamental concepts, such as homotopy groups and spectral sequences, are developed from a few axioms and are thus available in a broad variety of contexts. Many examples and applications in topology and algebra are discussed, including an introduction to rational homotopy theory in terms of both differential Lie algebras and De Rham algebras. The author describes powerful tools for homotopy classification problems, particularly for the classification of homotopy types and for the computation of the group homotopy equivalences. Applications and examples of such computations are given, including when the fundamental group is non-trivial. Moreover, the deep connection between the homotopy classification problems and the cohomology theory of small categories is demonstrated. The prerequisites of the book are few: elementary topology and algebra. Consequently, this account will be valuable for non-specialists and experts alike. It is an important supplement to the standard presentations of algebraic topology, homotopy theory, category theory and homological algebra.

New edition includes extensive revisions of the material on finite groups and Galois Theory. New problems added throughout.

The Mouse Nervous System provides a comprehensive account of the central nervous system of the mouse. The book is aimed at molecular biologists who need a book that introduces them to the anatomy of the mouse brain and spinal cord, but also takes them into the relevant details of development and organization of the area they have chosen to study. The Mouse Nervous System offers a wealth of new information for experienced anatomists who work on mice. The book serves as a valuable resource for researchers and graduate students in neuroscience. Systematic consideration of the anatomy and connections of all regions of the brain and spinal cord by the authors of the most cited rodent brain atlases A major section (12 chapters) on functional systems related to motor control, sensation, and behavioral and emotional states A detailed analysis of gene expression during development of the forebrain by Luis Puelles, the leading researcher in this area Full coverage of the role of gene expression during development and the new field of genetic neuroanatomy using site-specific recombinases Examples of the use of mouse models in the study of neurological illness

Broca's region has been in the news ever since scientists realized that particular cognitive functions could be localized to parts of the cerebral cortex. Its discoverer, Paul Broca, was one of the first researchers to argue for a direct connection between a concrete behavior--in this case, the use of language--and a specific cortical region. Today, Broca's region is perhaps the most famous part of the human brain, and for over a century, has persisted as the focus of intense research and numerous debates. The name has even penetrated mainstream culture through popular science and the theater. Broca's region is famous for a good reason: As language is one of the most distinctive human traits, the cognitive mechanisms that support it and the tissues in which these mechanisms are housed are also quite complex, and so have the potential to reveal a lot not only about how words, phrases, sentences, and grammatical rules are instantiated in neural tissue, but also, and more broadly, about how brain function relates to behavior. Paul Broca's discoveries were an important, driving force behind the more general effort to relate complex behavior to particular parts of the cerebral cortex, which, significantly, produced the first brain maps.These early studies also, however, suffered from the use of crude techniques, definitions, and distinctions, as well as from ill founded and misdirected assumptions. Although much has been discovered since Broca's work, even today, these problems have not been completely solved. Nonetheless, particularly as a result of important advances made in neuroimaging during the past two decades, Broca's region and all language areas are currently being investigated from every angle. Indeed, as the volume of research into the relations between brain and language has created several communities, each with its own concepts, methods, and considerations, it seemed that it was time to stop, get together, and reflect on the state of the art.This book is the result of that collective reflection, which took place primarily at the Broca's Region Workshop, held in Julich and Aachen, Germany, in June 2004. In it, Yosef Grodzinsky and Katrin Amunts tried to accomplish a nearly impossible task: to mix intellectual traditions and cultures, and juxtapose rather disparate bodies of knowledge, styles of reasoning, and forms of argumentation. Participants were scientists with diverse backgrounds; each invited to contribute his/her particular take, with the hope that a coherent, perhaps even novel, picture would emerge. All of the participants have a special interest in Broca's Region, and represent the myriad angles from which we currently approach it: neuroanatomy, physiology, evolutionary biology, cognitive psychology, clinical neurology, functional imaging, speech and language research, computational biology, and psycho-, neuro-, and theoretical linguistics. The book's main chapters are the contributions of the Workshop's participants and their research teams. Parts of the discussion during the Workshop are included to underscore the richness of viewpoints, and to give readers an idea of the level of interaction that took place. As Broca's region is such a historically significant concept and rich area, this book contains a collection of classic and recent-yet-classic papers. Along with cutting-edge science, Grodzinsky and Amunts want to remind readers of the celebrated past from which much can be learned. The historical chapters include the first two papers written by Paul Broca, as well some work by two of the most important neurologists of the nineteenth century, Ludwig Lichtheim and John Hughlings-Jackson. Also included are parts of twentieth century papers by Korbinian Brodmann, Roman Jakobson, Norman Geschwind, Harold Goodglass, and Jay Mohr. Because this book both reflects the state of the art in Broca's-region research and contains a tribute to its celebrated past, it will be a valuable resource for student and professional researchers. It will also stimulate further interdisciplinary research, which is a significant contribution, as the project called "Broca's region," encompassing the study of brain/language relations, is far from finished.

This is the only authoritative textbook on metabolic measurement of animals, ranging in mass from fruit flies to whales. It integrates a rigorous theoretical background with detailed practical guidelines for making actual measurements in the field and laboratory.

A 2014 Choice Magazine "Outstanding Academic Title" An Atlas of the World's Conifers is the first ever atlas of all known conifer species. It is based on locality information of ca. 37,000 collected herbarium specimens held in scientific institutions. As well as providing natural distribution maps for each species, Farjon and Filer give the reader comprehensive insight into the biogeography, diversity and conservation status of conifers on all continents, dispelling the widely held view that they are primarily a northern boreal plant group. Conifer diversity is analysed and presented with a taxonomic and geographic perspective. Distribution patterns are interpreted using the latest information on continental drift, dispersal and phylogeny. The entire dataset supporting the Atlas can be consulted and verified online. These data can also be used for further research and are an invaluable resource for anyone working on conifer systematics, biogeography or conservation. An Atlas of the World’s Conifers indicates the known distribution of all conifers including an analysis of their biogeography, diversity and conservation status. Also available from Brill is Aljos Farjon’s A Handbook of the World's Conifers, published in 2010 (ISBN 978 90 04 17718 5) which is a 2017 Choice Magazine "Outstanding Academic Title".