Starting in the nineteenth century the scholarly consensus has been to attribute the decline of the Spanish empire to structural rigidity, corrupt bureaucracy and repressive policies. In The Empire of the Cities, Aurelio Espinosa challenges these theories and offers groundbreaking insight into Spain’s political process and emphasizes early modern state formation. Spain’s empire should no longer be viewed simply as a symbol of royal absolutism and dominance. Rather it functioned as a collection of autonomous municipalities interconnected by a parliament that articulated domestic programs and foreign policy. Professor Espinosa also provides a more nuanced understanding of the monarchical government in revealing new insight into royal institutions and management procedures under Emperor Charles V. The Empire of the Cities offers a fascinating and penetrating look inside Spain’s political system that encouraged both expansionism and domestic stability.

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Active neuroscientists survey NSCs as potential tools for central nervous system and spinal cord repair by explaining their clinically significant fundamental properties, manipulations, and potential therapeutic paradigms. Their discussion of the fundamental biology of NSCs illustrates the signaling pathways that regulate stem cell division and differentiation, and defines the methods of NSC expansion and propagation, neuromorphogenesis, the factors determining cell fate both in vitro and in situ, and the induction of self-reparative processes within the brain. They also present strategies that may lead to fruitful clinical applications in the near future. These range from the replacement of degenerated, dysfunctional, or maldeveloped cells to the provision of factors that may protect, correct, recruit, promote self-repair, or mediate the connectivity of host cells.