While each of the previously known archives from the Third Dynasty of Ur has provided distinct views of Sumerian society, those from Iri-Saĝrig present an extraordinary range of new sources, depicting a cosmopolitan Sumerian/Akkadian city unlike any other from this period. In this publication, Marcel Sigrist and Tohru Ozaki present more than two thousand newly identified tablets, mostly from Iri-Saĝrig. This unique and extensive corpus elucidates the importance that Iri-Saĝrig represented politically, militarily, and culturally in Sumer. Although these tablets were not able to be cleaned, baked, or photographed, the authors’ transliterations are based on the original tablets, often after repeated collations. Moreover, access to so many well-preserved tablets made it possible to improve upon the readings and interpretations offered in previous publications. Volume 1 contains a catalog and classification of the texts by provenance, a list of month names and year formulas, another of inscriptions, a chronological listing of the texts, and extensive indexes of personal names, deities, toponyms, and selected words and phrases. Volume 2 presents the texts in transliteration with substantial commentary. This two-volume publication preserves and makes available to the scholarly community a significant segment of Iraq’s cultural legacy that otherwise might have been ignored or even lost. It will augment and enhance our understanding of the unique civilization of Mesopotamia in the late third millennium BCE.

The Code of Federal Regulations is the codification of the general and permanent rules published in the Federal Register by the executive departments and agencies of the Federal Government.

THE DISCOVERY OF INSULIN, C-PEPTIDE AND PROINSULlN, SPECIES DIFFERENCES Crude insulin was extracted and isolated from dog pancreases removed 7-1 ° weeks after ligation of the pancreatic duct for the first time in 1921 by Banting and Best. Its lifesaving properties were subsequently documented in pancreatectomized dogs in 1922. Only about six months elapsed from its discovery until systematic collection of calf and ox pancreases and, later, porcine pancreases was established and the blood glucose lowering effect in diabetics using the crude extract from these glands proven. It was not until 1960, however, that the primary structure of all three species of insulin, lO7 human, porcine and bovine, was elucidated . It then became evident that the differences between bovine, porcine and human insulin amounted to at mosl 3 amino acids. These apparently small differences have a significant impact on the physico-chemical characteristics of the three insulins which again affect, e.g., the rate of absorption of insulin lO9 preparations from the subcutaneous tissue and their immunogenicity, i.e.

Since the publication of the first edition of this book in 2010, an explosion of spectacular discoveries in the field of regeneration has compelled the current revisit of the field of Regenerative Nephrology. This second edition features subjects as diverse as age and gender influencing regenerative processes; mechanisms and pathways of premature cell senescence affecting kidney regeneration; the ways intrinsic regenerative processes can become subverted by noxious stressors eventuating in disease progression; novel mechanistic and engineering efforts to recreate functional kidney or its component parts; cell reprogramming and reconditioning as emerging tools of future regenerative efforts; and effects of various biologicals on kidney regeneration. These newer additions to the armamentarium of Regenerative Medicine and Nephrology have become an integral part of the second edition of the book. Cutting-edge investigations are summarized by the constellation of the most experienced contributing authors coming together from around the world under the umbrella of the second edition. - A significant expansion of section on induced pluripotent cells and trajectories of their differentiation. This will be followed by mechanisms and modalities of cell reprogramming for therapeutic purposes - A new section on tissue engineering of the kidney of interest to nephrologists and urologists - An entire section dedicated to causes of regenerative failure with the emphasis on recent discoveries of senescent cells in kidney disease, pathologic effects of senescent cells, advents in senotherapies and rejuvenation therapies - A vastly expanded section on pharmacotherapies promoting kidney regeneration, trials of engineered organs, manufacturing in regenerative medicine and smooth transition to the clinical trials, with an update on some ethical issues

Semantic Web technologies enable people to create data stores on the Web, build vocabularies, and write rules for handling data. They have been in use for several years now, and knowledge extraction and knowledge discovery are two key aspects investigated in a number of research fields which can potentially benefit from the application of semantic web technologies, and specifically from the development and reuse of ontologies. This book, Applications and Practices in Ontology Design, Extraction, and Reasoning, has as its main goal the provision of an overview of application fields for semantic web technologies. In particular, it investigates how state-of-the-art formal languages, models, methods, and applications of semantic web technologies reframe research questions and approaches in a number of research fields. The book also aims to showcase practical tools and background knowledge for the building and querying of ontologies. The first part of the book presents the state-of-the-art of ontology design, applications and practices in a number of communities, and in doing so it provides an overview of the latest approaches and techniques for building and reusing ontologies according to domain-dependent and independent requirements. Once the data is represented according to ontologies, it is important to be able to query and reason about them, also in the presence of uncertainty, vagueness and probabilities. The second part of the book covers some of the latest advances in the fields of ontology, semantics and reasoning, without losing sight of the book’s practical goals.