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A balanced treatment of the theories, methodologies, and design issues involved in clinical trials using statistical methods There has been enormous interest and development in Bayesian adaptive designs, especially for early phases of clinical trials. However, for phase III trials, frequentist methods still play a dominant role through controlling type I and type II errors in the hypothesis testing framework. From practical perspectives, Clinical Trial Design: Bayesian and Frequentist Adaptive Methods provides comprehensive coverage of both Bayesian and frequentist approaches to all phases of clinical trial design. Before underpinning various adaptive methods, the book establishes an overview of the fundamentals of clinical trials as well as a comparison of Bayesian and frequentist statistics. Recognizing that clinical trial design is one of the most important and useful skills in the pharmaceutical industry, this book provides detailed discussions on a variety of statistical designs, their properties, and operating characteristics for phase I, II, and III clinical trials as well as an introduction to phase IV trials. Many practical issues and challenges arising in clinical trials are addressed. Additional topics of coverage include: Risk and benefit analysis for toxicity and efficacy trade-offs Bayesian predictive probability trial monitoring Bayesian adaptive randomization Late onset toxicity and response Dose finding in drug combination trials Targeted therapy designs The author utilizes cutting-edge clinical trial designs and statistical methods that have been employed at the world's leading medical centers as well as in the pharmaceutical industry. The software used throughout the book is freely available on the book's related website, equipping readers with the necessary tools for designing clinical trials. Clinical Trial Design is an excellent book for courses on the topic at the graduate level. The book also serves as a valuable reference for statisticians and biostatisticians in the pharmaceutical industry as well as for researchers and practitioners who design, conduct, and monitor clinical trials in their everyday work.

Lively and engaging, this invaluable handbook puts the continent's great cities and regions at your fingertips, and includes all the highlights plus the very best off-the-beaten-path experiences that make any visit to Europe memorable. Packed with experienced insider tips, Europe For Dummies offers: Essential information on London, Edinburgh, Dublin, Paris, Amsterdam, Munich & the Bavarian Alps, Vienna, Prague, Rome, Florence & Tuscany, Venice, Barcelona, and Athens A select choice of favorite hotels and eateries in every destination and price category Indispensable foreign language glossaries Advice on everything from planning a sensible itinerary and getting the best deals to using public transit and catching must-see sights Helpful tips on converting currencies, overcoming language barrier, avoiding crowds, and sampling local cuisine

"List of publications of the Bureau of American Ethnology (comp. by Frederick Webb Hodge)":

Asia's premier business magazine. The magazine reports on politics, business, economics, technology and social and cultural issues throughout Asia, with a particular emphasis on both Southeast Asia and China.

Enjoy sightseeing and shopping in bustling Edinburgh and Glasgow or explore unspoiled scenery and welcoming towns in the Hebridean Islands, Southern Scotland, Tayside, and the Northeast. Go from the Highlands to the Lowlands. Hike, canoe, or just relax at Loch Lomand. This friendly guide gives you the scoop on: Edinburgh Old Town, with its intriguing winding alleyways Accommodations that range from sumptuous 17th century hotel furnished with Gothic antiques to a secluded seaside escape, and from a 17th century laird’s house to a sleek, modern and minimalist hotel Enjoying a pint of lager in a rustic pub where the barmen wear kilts and you don’t tip or touring distinctive distilleries Cathedrals, castles and historic sites like the Calanais Standing Stones (the "Scottish Stonehenge"), Edinburgh Castle that holds the historic Stone of Destiny and Scotland’s crown jewels, Doune Castle, made famous by the film Monty Python and the Holy Grail, and Glasgow Cathedral Storied golf courses such as Muirfield, Royal Troon, and St. Andrews in the country credited with developing the sport Touring Sir Walter Scott’s mansion, Abbotsford, with it’s incredible library, relics, and mementos, or paying homage to poet Robert Burns at numerous sites Shopping for everything from fine wool knits to Caithness glass paper weights to Edinburgh Crystal to tartans and kilts to Highland Stoneware Like every For Dummies travel guide, Scotland For Dummies, 5th Edition includes: Down-to-earth trip-planning advice What you shouldn’t miss — and what you can skip The best hotels and restaurants for every budget Whether you’re looking for fun nightlife or the legendary Loch Ness monster…whether you want to explore art galleries and museums or walk craggy seacoasts, this guide gives you the flavor of Scotland so enchantingly you can almost hear the bagpipes.