Following an introductory overview, Hyperthermia In Cancer Treatment: A Primer comprehensively describes the biological reasons for associating hyperthermia with radiation and chemotherapy and the biological and clinical effects of hyperthermia on cancerous and normal tissues. The volume’s 20 chapters are arranged in three principal parts: physical and methodological studies, biologic principles, and clinical studies.

Hyperthermia as a tool for the treatment of malignant disease is rapidly becoming a clinical reality. In this book I am attempting to summarize the known biological and physical underpinnings that have led to this development. I also present a compilation of existing clinical results, limited as these are. My aim is to provide oncologists and other physicians with up-to-date information on this modality, which is both new and old, as well as to make available to biologists, physicists and engineers sum maries of currently available information on specific areas of hyperthermic research. Many people have helped me with this book. Specifically, thanks are due to Drs. William Dewey, Jean Dutreix, Peter Fessenden, Gloria Li, and Jane Marmor. Their suggestions have been invaluable. I hope that not too many errors and omissions have crept into the volume, but in any case, for these I have only myself to blame. I also wish to express my appreciation to David Betten and Marie Graham for their help. Most of this material was written while I was on sabbatical leave on the shores of Lake Atitlan in Guatemala. There I enjoyed the hospitality of a gracious, friendly, and proud people who deserve better than fate seems to have in store for them.

Nanomaterials for Magnetic and Optical Hyperthermia Applications focuses on the design, fabrication and characterization of nanomaterials (magnetic, gold and hybrid magnetic-gold nanoparticles) for in vitro and in vivo hyperthermia applications, both as standalone and adjuvant therapy in combination with chemotherapy. The book explores the potential for more effective cancer therapy solutions through the synergistic use of nanostructured materials as magnetic and optical hyperthermia agents and targeted drug delivery vehicles, while also discussing the challenges related to their toxicity, regulatory and translational aspects. In particular, the book focuses on the design, synthesis, biofunctionalization and characterization of nanomaterials employed for magnetic and optical hyperthermia. This book will be an important reference resource for scientists working in the areas of biomaterials and biomedicine seeking to learn about the potential of nanomaterials to provide hyperthermia solutions. - Explores the design of efficient nanomaterials for hyperthermia applications, allowing readers to make informed materials selection decisions - Discusses the biofunctionalization of a range of nanomaterials and their interaction with living systems - Provides an overview of the current clinical applications of nanomaterials in hyperthermia treatment

The effects of global warming on human health factors with special regards to our brain function are still not well understood. There is an urgent need to expand our knowledge on the effects of hot environment on our brain functions in healthy and in diseased populations. It is still unclear whether infectious events, traumatic injuries, metabolic diseases, carcinogenic events, cardiovascular and respiratory functions will be adversely affected by the rise in global temperature or whether environmental pollutants, such as nanoparticles entered into our body system will produce more damage at high ambient temperatures. This book aims to answer these questions based on recent research carried out by top experts in the field from the USA (11 chapters), Europe (8) chapters), the Middle East (3 chapters), Asia (2 chapters) and Canada (1). These chapters are written in review style and embedded with the author’s new and original data in relation to the current knowledge in the field. The book is highly interesting to the first time readers, beginners and students alike as well as provides in-depth knowledge to the professionals. In addition, prospects for future research and recommendations are clearly indicated in each chapter for future growth of the subject in this highly emerging new discipline. Describes the importance of brain temperature and hyperthermia in disease processes Presents research on the first observations on Nanoparticles that worsen the outcome of hyperthermia Discusses the effects of hyperthermia on the blood-brain and blood-cerebrospinal fluid barriers

The second edition of a succinct and portable text reviewing the clinical approach to emergency medicine and critical care.

Now in paperback, the second edition of the Oxford Textbook of Critical Care is a comprehensive multi-disciplinary text covering all aspects of adult intensive care management. Uniquely this text takes a problem-orientated approach providing a key resource for daily clinical issues in the intensive care unit. The text is organized into short topics allowing readers to rapidly access authoritative information on specific clinical problems. Each topic refers to basic physiological principles and provides up-to-date treatment advice supported by references to the most vital literature. Where international differences exist in clinical practice, authors cover alternative views. Key messages summarise each topic in order to aid quick review and decision making. Edited and written by an international group of recognized experts from many disciplines, the second edition of the Oxford Textbook of Critical Careprovides an up-to-date reference that is relevant for intensive care units and emergency departments globally. This volume is the definitive text for all health care providers, including physicians, nurses, respiratory therapists, and other allied health professionals who take care of critically ill patients.

The next generation of oncological hyperthermia involves the medical innovation of selectively heating up the malignant cells of the body in a controlled way. The easily-distinguishable biophysical and physiological characteristics of cancer cells and their immediate environment are the focus of the targeted energy delivery of this treatment. This heterogenic heating concept breaks with the homogeneous nature of conventional hyperthermia, where an isothermally equal temperature is applied to the large surface area of a solid tumor. Due to its selectivity, the new concept enables the usage of a significantly lower energy, making it safer, less toxic, and easier to use. This book shows the challenges facing oncological hyperthermia, and highlights clinical results obtained in various countries. It also presents discussions about the theoretical basis of the method, adding some technical discussions and clarifying the most difficult points of its design. The contributions dealing with clinical results use state-of-art conventional therapies with complementary hyperthermia and show the advantages of such a combination.

Oncothermia is the next generation medical innovation that delivers selective, controlled and deep energy for cancer treatment. The basic principles for oncothermia stem from oncological hyperthermia, the oldest approach to treating cancer. Nevertheless, hyperthermia has been wrought with significant controversy, mostly stemming from shortcomings of controlled energy delivery. Oncothermia has been able to overcome these insufficiencies and prove to be a controlled, safe and efficacious treatment option. This book is the first attempt to elucidate the theory and practice of oncothermia, based on rigorous mathematical and biophysical analysis, not centered on the temperature increase. It is supported by numerous in-vitro and in-vivo findings and twenty years of clinical experience. This book will help scientists, researchers and medical practitioners in understanding the scientific and conceptual underpinnings of oncothermia and will add another valuable tool in the fight against cancer. Professor Andras Szasz is the inventor of oncothermia and the Head of St Istvan University's Biotechnics Department in Hungary. He has published over 300 papers and lectured at various universities around the world. Dr. Oliver Szasz is the managing director of Oncotherm, the global manufacturer and distributor of medical devices for cancer treatment used in Europe & Asia since the late 1980s. Dr. Nora Szasz is currently a management consultant in healthcare for McKinsey & Co.

This is a user-friendly monograph designed for medical students as well as graduate students and postdoctoral trainees in medicine and other health-related sciences who need a comprehensive overview of thermoregulation. It presents the bases of the modern concepts in thermal physiology and pathophysiology, bringing together the disciplines encompassed by this highly integrative field ? physiology, anatomy, biophysics, molecular and cellular biology, pharmacology, neuroscience, pathology, medicine, and others ? into a clear and concise form that can be read comfortably in a relatively short time. This text was conceived by the Commission on Thermal Physiology of the International Union of Physiological Sciences in response to its concern over the inadequate and outdated coverage of this topic in traditional textbooks. The membership of this Commission comprises international experts in each of the subfields of thermal physiology, with extensive research and teaching experience in their respective specialties. They are the authors of the chapters of this indispendable textbook.

Hyperthermia has been found to be of great benefit in combination with radiation therapy or chemotherapy in the management of patients with difficult and com plicated tumor problems. It has been demonstrated to increase the efficacy, of ionising radiation when used locally but also has been of help in combination with systemic chemotherapy where hyperthermia is carried out to the total body. Problems remain with regard to maximizing the effects of hyperthermia as in fluenced by blood flow, heat loss, etc. The present volume defines the current knowledge relative to hyperthermia with radiation therapy and/or chemotherapy, giving a comprehensive overview of its use in cancer management. Philadelphia/Hamburg, June 1995 L.W. BRADY H.-P. HEILMANN Preface In an attempt to overcome tumor resistance, hypoxia, or unfavorable tumor condi tions, oncological research has come to focus on gene therapy, immunotherapy, new cytotoxic agents, and increasingly sophisticated radiotherapy. Radiation research has been directed towards heavy particle therapy and modification of the radiation response by either protecting or sensitizing agents. Improved dose localization using rotational or conformal strategies has also been implemented. Recently, changes in radiation fractionation schedules have shown promise of better results. Hyperthermia in cancer therapy can be viewed similarly as another means to increase the sensitivity of tumors to radio- and chemotherapy.