Various approaches have been developed to evaluate the consequences of spatial structure on evolution in subdivided populations. This book is both a review and new synthesis of several of these approaches, based on the theory of spatial genetic structure. François Rousset examines Sewall Wright's methods of analysis based on F-statistics, effective size, and diffusion approximation; coalescent arguments; William Hamilton's inclusive fitness theory; and approaches rooted in game theory and adaptive dynamics. Setting these in a framework that reveals their common features, he demonstrates how efficient tools developed within one approach can be applied to the others. Rousset not only revisits classical models but also presents new analyses of more recent topics, such as effective size in metapopulations. The book, most of which does not require fluency in advanced mathematics, includes a self-contained exposition of less easily accessible results. It is intended for advanced graduate students and researchers in evolutionary ecology and population genetics, and will also interest applied mathematicians working in probability theory as well as statisticians.

Genetics and Evolution of Infectious Diseases, Third Edition discusses the evolving field of infectious diseases and their continued impact on the health of populations, especially in resource-limited areas of the world where they must confront the dual burden of death and disability due to infectious and chronic illnesses. Although substantial gains have been made in public health interventions for the treatment, prevention, and control of infectious diseases, in recent decades the world has witnessed the emergence of the human immunodeficiency virus (HIV) and the COVID-19 pandemic, increasing antimicrobial resistance, and the emergence of many new bacterial, fungal, parasitic, and viral pathogens. Fully updated and revised, this new edition presents the consequences of such diseases, the evolution of infectious diseases, the genetics of host-pathogen relationship, and the control and prevention strategies that are, or can be, developed. This book offers valuable information to biomedical researchers, clinicians, public health practitioners, decisions-makers, and students and postgraduates studying infectious diseases, microbiology, medicine, and public health that is relevant to the control and prevention of neglected and emerging worldwide diseases. - Takes an integrated approach to infectious diseases - Provides the latest developments in the field of infectious diseases - Focuses on the contribution of evolutionary and genomic studies for the study and control of transmissible diseases - Includes updated and revised contributions from leading authorities, along with six new chapters

J. B. S. Haldane, R. A. Fisher and Sewall Wright simultaneously, and largely independently, laid the foundations of population genetics and the mathematical theory of evolution. Hal dane was born on November 5, 1892. Although he primarily worked at the University College London (UCL), in 1957 he resigned from the UCL and joined the Indian Statistical Institute, Calcutta (India) as a Research Professor. In celebration of his birth centenary, the Indian Statistical Institute organized an International Conference on Human Genetics from 15 to 19 December, 1992. The prime motive in holding this Conference was to bring together a group of scientists - geneticists, anthropologists, clinicians and statisticians - to evaluate the impact of Haldane's contributions to various areas of human genetics, and also to review recent developments in the subject. Session and lecture themes were so chosen that they covered areas theoretical and applied, classical and emerging. Speakers were then identified and invited to deliver lectures on these themes. Manuscripts of all invited presentations and a selected number of contributed presentations were considered for inclusion in this Proceed ings Volume. Each manuscript was reviewed by at least one Conference participant, which resulted in revision of several manuscripts and rejection of some. This volume is a collection of the manuscripts which have been 'accepted' after the review-process. The Conference began with the "J. B. S. Haldane Centenary Lecture" delivered by C. R. Rao.

In 1992 the National Research Council issued DNA Technology in Forensic Science, a book that documented the state of the art in this emerging field. Recently, this volume was brought to worldwide attention in the murder trial of celebrity O. J. Simpson. The Evaluation of Forensic DNA Evidence reports on developments in population genetics and statistics since the original volume was published. The committee comments on statements in the original book that proved controversial or that have been misapplied in the courts. This volume offers recommendations for handling DNA samples, performing calculations, and other aspects of using DNA as a forensic toolâ€"modifying some recommendations presented in the 1992 volume. The update addresses two major areas: Determination of DNA profiles. The committee considers how laboratory errors (particularly false matches) can arise, how errors might be reduced, and how to take into account the fact that the error rate can never be reduced to zero. Interpretation of a finding that the DNA profile of a suspect or victim matches the evidence DNA. The committee addresses controversies in population genetics, exploring the problems that arise from the mixture of groups and subgroups in the American population and how this substructure can be accounted for in calculating frequencies. This volume examines statistical issues in interpreting frequencies as probabilities, including adjustments when a suspect is found through a database search. The committee includes a detailed discussion of what its recommendations would mean in the courtroom, with numerous case citations. By resolving several remaining issues in the evaluation of this increasingly important area of forensic evidence, this technical update will be important to forensic scientists and population geneticistsâ€"and helpful to attorneys, judges, and others who need to understand DNA and the law. Anyone working in laboratories and in the courts or anyone studying this issue should own this book.

Providing an essential foundation for evolutionary theory, this comprehensive volume examines patterns of genetic variation within natural insect populations, and explores the underlying mechanisms that lead to the genetic divergence of coexisting organisms. In particular, the text investigates current research on finescale genetic structure in natural insect populations. Internationally renowned scientists offer a wealth of current information not previously published. Part I present case studies of adaptive genetic structure in natural insect populations, including a critical discussion of the strenghts and weaknesses of the experimental methods employed. Part II addresses the ecological mechanisms that produce adaptive genetic structure in natural insect populations. Part III describes how behavioral and life-history patterns influence genetic structure. Finally, Part IV combines theoretical and empirical approaches linking genetic structure at the population level with larger-scale patterns of variation, such as host race formation and speciation. This broad-ranging, interdisciplinary source of information supplies a thorough examination of the mechanisms that promote and impede genetic structure in natural insect populations. It is a book that will be of interest to undergraduate and graduate students, and to researchers in the fields of ecology, evolution, insect and plant systems, entomology, and population genetics.

The present monograph develops a versatile and profound mathematical perspective of the Wright--Fisher model of population genetics. This well-known and intensively studied model carries a rich and beautiful mathematical structure, which is uncovered here in a systematic manner. In addition to approaches by means of analysis, combinatorics and PDE, a geometric perspective is brought in through Amari's and Chentsov's information geometry. This concept allows us to calculate many quantities of interest systematically; likewise, the employed global perspective elucidates the stratification of the model in an unprecedented manner. Furthermore, the links to statistical mechanics and large deviation theory are explored and developed into powerful tools. Altogether, the manuscript provides a solid and broad working basis for graduate students and researchers interested in this field.

This book explores the shift from hunting and gathering to agriculture as a way of life and the implications of this neolithic transition for the genetic structure of European populations. Originally published in 1984. The Princeton Legacy Library uses the latest print-on-demand technology to again make available previously out-of-print books from the distinguished backlist of Princeton University Press. These editions preserve the original texts of these important books while presenting them in durable paperback and hardcover editions. The goal of the Princeton Legacy Library is to vastly increase access to the rich scholarly heritage found in the thousands of books published by Princeton University Press since its founding in 1905.

Tropical climates, which occur between 23°30'N and S latitude (Jacob 1988), encompass a wide variety of plant communities (Hartshorn 1983, 1988), many of which are diverse in their woody floras. Within this geographic region, temperature and the amount and seasonality of rainfall define habitat types (UNESCO 1978). The F AO has estimated that there 1 are about 19 million km of potentially forested area in the global tropics, of which 58% were estimated to still be in closed forest in the mid-1970s (Sommers 1976; UNESCO 1978). Of this potentially forested region, 42% is categorized as dry forest lifezone, 33% is tropical moist forest, and 25% is wet or rain forest (Lugo 1988). The species diversity of these tropical habitats is very high. Raven (1976, in Mooney 1988) estimated that 65% of the 250,000 or more plant species of the earth are found in tropical regions. Of this floristic assemblage, a large fraction are woody species. In the well-collected tropical moist forest of Barro Colorado Island, Panama, 39. 7% (481 of 1212 species) of the native phanerogams are woody, arborescent species (Croat 1978). Another 21. 9% are woody vines and lianas. Southeast Asian Dipterocarp forests may contain 120-200 species of trees per hectare (Whitmore 1984), and recent surveys in upper Amazonia re corded from 89 to 283 woody species ~ 10 cm dbh per hectare (Gentry 1988). Tropical communities thus represent a global woody flora of significant scope.

Although the long-term processes of evolution are selection and mutation, the infrastructure of a population is a no less important force in determining the distributions of genetic characteristics observable within populations. In small populations, and in particular in human populations, complex patterns of genealogical relationship between individuals can be an important factor in the maintenance of genetic variability. The aim of this book is to develop the quantitative theory of the interrelationship between the genealogical and the genetic structures of a population. Aspects of other structural features, such as migration patterns, are also discussed, but are not central to the development. There are three major aspects; each comprises two chapters of the text. First, genealogical relationships are characterized in a way which can illuminate their genetic consequences. Second, the evolutionary aspects of genealogical structure are developed. Finally, the last two chapters present methods of characterizing the complete structure of a genealogy, and of computing relevant parameters of genealogical structure; these topics are of relevance to genetic epidemiology as well as to population genetics.