This e-book will review special features of the cerebral circulation and how they contribute to the physiology of the brain. It describes structural and functional properties of the cerebral circulation that are unique to the brain, an organ with high metabolic demands and the need for tight water and ion homeostasis. Autoregulation is pronounced in the brain, with myogenic, metabolic and neurogenic mechanisms contributing to maintain relatively constant blood flow during both increases and decreases in pressure. In addition, unlike peripheral organs where the majority of vascular resistance resides in small arteries and arterioles, large extracranial and intracranial arteries contribute significantly to vascular resistance in the brain. The prominent role of large arteries in cerebrovascular resistance helps maintain blood flow and protect downstream vessels during changes in perfusion pressure. The cerebral endothelium is also unique in that its barrier properties are in some way more like epithelium than endothelium in the periphery. The cerebral endothelium, known as the blood-brain barrier, has specialized tight junctions that do not allow ions to pass freely and has very low hydraulic conductivity and transcellular transport. This special configuration modifies Starling's forces in the brain microcirculation such that ions retained in the vascular lumen oppose water movement due to hydrostatic pressure. Tight water regulation is necessary in the brain because it has limited capacity for expansion within the skull. Increased intracranial pressure due to vasogenic edema can cause severe neurologic complications and death.

Get a complete look into modern traffic engineering solutions Traffic Engineering Handbook, Seventh Edition is a newly revised text that builds upon the reputation as the go-to source of essential traffic engineering solutions that this book has maintained for the past 70 years. The updated content reflects changes in key industry standards, and shines a spotlight on the needs of all users, the design of context-sensitive roadways, and the development of more sustainable transportation solutions. Additionally, this resource features a new organizational structure that promotes a more functionally-driven, multimodal approach to planning, designing, and implementing transportation solutions. A branch of civil engineering, traffic engineering concerns the safe and efficient movement of people and goods along roadways. Traffic flow, road geometry, sidewalks, crosswalks, cycle facilities, shared lane markings, traffic signs, traffic lights, and more—all of these elements must be considered when designing public and private sector transportation solutions. Explore the fundamental concepts of traffic engineering as they relate to operation, design, and management Access updated content that reflects changes in key industry-leading resources, such as the Highway Capacity Manual (HCM), Manual on Uniform Traffic Control Devices (MUTCD), AASSHTO Policy on Geometric Design, Highway Safety Manual (HSM), and Americans with Disabilities Act Understand the current state of the traffic engineering field Leverage revised information that homes in on the key topics most relevant to traffic engineering in today's world, such as context-sensitive roadways and sustainable transportation solutions Traffic Engineering Handbook, Seventh Edition is an essential text for public and private sector transportation practitioners, transportation decision makers, public officials, and even upper-level undergraduate and graduate students who are studying transportation engineering.

Considers the application of modern control engineering on digital computers with a view to improving productivity and product quality, easing supervision of industrial processes and reducing energy consumption and pollution. The topics covered may be divided into two main subject areas: (1) applications of digital control - in the chemical and oil industries, in water turbines, energy and power systems, robotics and manufacturing, cement, metallurgical processes, traffic control, heating and cooling; (2) systems theoretical aspects of digital control - adaptive systems, control aspects, multivariable systems, optimization and reliability, modelling and identification, real-time software and languages, distributed systems and data networks. Contains 84 papers.

Drawing on the insights of artists, philosophers, anthropologists, and other unusual sources, this first look inside the successful Japanese company addresses not just the question of how do we make good, responsible products, but the very basic questions that nag at us as we try to figure out the moral center--the purpose--of our everyday work.

Object-Oriented Analysis and Design for Information Systems clearly explains real object-oriented programming in practice. Expert author Raul Sidnei Wazlawick explains concepts such as object responsibility, visibility and the real need for delegation in detail. The object-oriented code generated by using these concepts in a systematic way is concise, organized and reusable. The patterns and solutions presented in this book are based in research and industrial applications. You will come away with clarity regarding processes and use cases and a clear understand of how to expand a use case. Wazlawick clearly explains clearly how to build meaningful sequence diagrams. Object-Oriented Analysis and Design for Information Systems illustrates how and why building a class model is not just placing classes into a diagram. You will learn the necessary organizational patterns so that your software architecture will be maintainable. - Learn how to build better class models, which are more maintainable and understandable. - Write use cases in a more efficient and standardized way, using more effective and less complex diagrams. - Build true object-oriented code with division of responsibility and delegation.