Diabetes mellitus is a major public health problem affecting over 415 million people in the world. Extensive research over the decades and the recent discovery of new medicines have revolutionized our understanding and treatment of both type 2 diabetes and type 1 diabetes mellitus. This book contains selected topics that describe recent advances in research, and state of the art treatment of the two types of diabetes mellitus and their complications. The topics encompass epidemiology and pathogenesis of diabetes, clinical features, diagnosis and treatment of diabetes and related complications. The chapters contain essential background materials, as well as recent advances in researches in different aspects of diabetes mellitus. The books is expected to be useful for researchers, research students, as well as for the clinicians engaged in diabetes care and diabetes research.

As type 2 diabetes continues its rise in prevalence worldwide, there is an increasing need to study it and describe successful treatments. There are several options for treatment, including oral medications, diet and lifestyle modification, and insulin therapy. Knowing which method to select and how to apply it relies on several clinical guidelines that are updated every year by the American Diabetes Association. This new edition of Medical Management of Type 2 Diabetes provides care providers with the answers to their questions about implementing care. All of the contributors are experts in their fields, and they define the disease, including the progressive nature of type 2 diabetes; cardiovascular, microvascular, and neurological complications; care methodologies for special situations; and behavior change. All guidelines and standards have been updated with the latest developments in research, advances in medications and medical devices, and new understandings of how to effectively work with the patient.

The third edition of Clinical Care of the Diabetic Foot has been fully revised and updated, and continues to be the essential handbook on foot care and the treatment of the diabetic foot. The diabetic foot is typically the victim of nerve damage, micro- and macrovascular disease, and faulty healing, mechanisms that without proper care can lead to amputation. More than 80,000 diabetes-related amputations are performed in the United States each year, but non-specialist primary care providers, as well as residents, nurses, and diabetes educators, can help prevent this devastating, life-altering, and expensive complication. Healthcare professionals and medical students alike will find that this concise, well-indexed, and updated guide offers practical advice on detecting and managing diabetes-related foot complications.

Although the vast majority of diabetes cases (type 1 and type 2) are polygenic diseases, research, funded by the American Diabetes Association, has found that some forms of diabetes, distinct from type 1 or type 2 diabetes, are caused by single gene mutations. It has been estimated that these monogenic forms of diabetes account for up to five percent of all diabetes cases. In addition to monogenic diabetes, there are other atypical causes of diabetes, including: genetic defects in insulin action; diseases of the exocrine pancreas; and endocrinopathies. Given recent advances in our understanding of sub-types of diabetes, the time has come for a book on how to correctly diagnose and treat patients with atypical forms of this disorder. The book will be divided into three parts, each exploring distinct categories of atypical diabetes. Part I: Monogenic Diabetes: Genetic Defects of β-cell development and function; Part II: Insulin resistance, genetic defects in insulin action, and diseases of exocrine pancreas; Part III: Endocrinopathies, Immune-mediated diabetes, Diabetes of Unknown cause, and Other genetic syndromes sometimes associated with diabetes.

Diabetes clinical practice is a life-long learning experience, and the insights presented in Diabetes in Practice will facilitate a deeper knowledge of the complex nature of diabetes and its comorbidities for physicians, nurse practitioners, registered dietitians, diabetes educators, and students. Diabetes in Practice offers a deep look into years of the professional practice of clinical diabetes. The 49 case studies Boris Draznin, MD, PhD, has assembled cover a wide array of diabetes cases involving atypical presentations to those addressing ketoacidosis and hypoglycemia, continuous glucose monitoring and insulin pumps, and diabetes co-occurring with cancer and autoimmune conditions. Each case study includes expert review from long-term diabetes practitioners to help you in your daily interactions with patients and enhance your understanding of diabetes diagnosis and treatment challenges.

Intended for diabetes researchers and medical professionals who work closely with patients with diabetes, this newly updated and expanded edition provides new perspectives and direct insight into the causes and consequences of this serious medical condition from one of the foremost experts in the field. Using the latest scientific and medical developments and trends, readers will learn how to identify, prevent, and treat this challenging phenomenon within the parameters of the diabetes care regimen.

In recent years, human studies have made enormous contributions towards an understanding of the genetic basis of diabetes mellitus; however, most of the experimentation needed for the invention and testing of novel therapeutic approaches cannot be performed in humans. Thus, there is no alternative to appropriate animal models. In Animal Models in Diabetes Research, expert researchers explore the current status of the most important models and procedures in order to provide a timely resource in experimental diabetology. The first half of the volume serves as a comprehensive overview on our current knowledge of the pathogenesis and pathophysiology of diabetes in animal models through a series of reviews in model strains. The book then continues with vital, established protocols that are employed in the characterization and study of animal models of diabetes. As a volume in the highly successful Methods in Molecular BiologyTM series, this work contains the type of detailed description and key implementation advice necessary to achieve successful results. Authoritative and cutting-edge, Animal Models in Diabetes Research delivers essential content that will be an important resource to advance diabetes research in the years to come.

In recent years, there has been a growing awareness of the multiple interrelationships between depression and various physical diseases. The WPA is providing an update of currently available evidence on these interrelationships by the publication of three books, dealing with the comorbidity of depression with diabetes, heart disease and cancer. Depression is a frequent and serious comorbid condition in diabetes, which adversely affects quality of life and the long-term prognosis. Co-occurrent depression presents peculiar clinical challenges, making both conditions harder to manage. Depression and Diabetes is the first book devoted to the interaction between these common disorders. World leaders in diabetes, depression and public health synthesize current evidence, including some previously unpublished data, in a concise, easy-to-read format. They provide an overview of the epidemiology, pathogenesis, medical costs, management, and public health and cultural implications of the comorbidity between depression and diabetes. The book describes how the negative consequences of depression in diabetes could be avoided, given that effective depression treatments for diabetic patients are available. Its practical approach makes the book ideal for all those involved in the management of these patients: psychiatrists, psychologists, diabetologists, general practitioners, diabetes specialist nurses and mental health nurses.