This book focuses on computational intelligence techniques and their applications — fast-growing and promising research topics that have drawn a great deal of attention from researchers over the years. It brings together many different aspects of the current research on intelligence technologies such as neural networks, support vector machines, fuzzy logic and evolutionary computation, and covers a wide range of applications from pattern recognition and system modeling, to intelligent control problems and biomedical applications. Fundamental concepts and essential analysis of various computational techniques are presented to offer a systematic and effective tool for better treatment of different applications, and simulation and experimental results are included to illustrate the design procedure and the effectiveness of the approaches./a

Computational Intelligence (CI) has been a tremendously active area of - search for the past decade or so. There are many successful applications of CI in many sub elds of biology, including bioinformatics, computational - nomics, protein structure prediction, or neuronal systems modeling and an- ysis. However, there still are many open problems in biology that are in d- perate need of advanced and e cient computational methodologies to deal with tremendous amounts of data that those problems are plagued by. - fortunately, biology researchers are very often unaware of the abundance of computational techniques that they could put to use to help them analyze and understand the data underlying their research inquiries. On the other hand, computational intelligence practitioners are often unfamiliar with the part- ular problems that their new, state-of-the-art algorithms could be successfully applied for. The separation between the two worlds is partially caused by the use of di erent languages in these two spheres of science, but also by the relatively small number of publications devoted solely to the purpose of fac- itating the exchange of new computational algorithms and methodologies on one hand, and the needs of the biology realm on the other. The purpose of this book is to provide a medium for such an exchange of expertise and concerns. In order to achieve the goal, we have solicited cont- butions from both computational intelligence as well as biology researchers.

An invaluable tool in Bioinformatics, this unique volume provides both theoretical and experimental results, and describes basic principles of computational intelligence and pattern analysis while deepening the reader's understanding of the ways in which these principles can be used for analyzing biological data in an efficient manner. This book synthesizes current research in the integration of computational intelligence and pattern analysis techniques, either individually or in a hybridized manner. The purpose is to analyze biological data and enable extraction of more meaningful information and insight from it. Biological data for analysis include sequence data, secondary and tertiary structure data, and microarray data. These data types are complex and advanced methods are required, including the use of domain-specific knowledge for reducing search space, dealing with uncertainty, partial truth and imprecision, efficient linear and/or sub-linear scalability, incremental approaches to knowledge discovery, and increased level and intelligence of interactivity with human experts and decision makers Chapters authored by leading researchers in CI in biology informatics. Covers highly relevant topics: rational drug design; analysis of microRNAs and their involvement in human diseases. Supplementary material included: program code and relevant data sets correspond to chapters.

This book features novel research papers spanning many different subfields in bioinformatics and computational biology, presenting the latest research on the practical applications to promote fruitful interactions between young researchers in different areas related to the field. Clearly, biology is increasingly becoming a science of information, requiring tools from the computational sciences. To address these challenges, we have seen the emergence of a new generation of interdisciplinary scientists with a strong background in the biological and computational sciences. PACBB'21 expects to contribute to this effort by encouraging a successful collaboration of researchers in different areas related to bioinformatics. The PACBB'21 technical program included 17 papers covering many different subfields in bioinformatics and computational biology. Therefore, this conference, held in Salamanca (Spain), definitely promotes the collaboration of scientists from different research groups and with different backgrounds (computer scientists, mathematicians, biologists) to reach breakthrough solutions for these challenges.

A detailed overview of current research in kernel methods and their application to computational biology.

Computational Intelligence (CI) has emerged as a novel and highly diversified paradigm supporting the design, analysis and deployment of intelligent systems. This book presents a careful selection of the field that very well reflects the breadth of the discipline. It covers a range of highly relevant and practical design principles governing the development of intelligent systems in data mining, robotics, bioinformatics, and intelligent tutoring systems. The lucid presentations, coherent organization, breadth and the authoritative coverage of the area make the book highly attractive for everybody interested in the design and analysis of intelligent systems.

These original contributions provide a current sampling of AI approaches to problems of biological significance; they are the first to treat the computational needs of the biology community hand-in-hand with appropriate advances in artificial intelligence. The enormous amount of data generated by the Human Genome Project and other large-scale biological research has created a rich and challenging domain for research in artificial intelligence. These original contributions provide a current sampling of AI approaches to problems of biological significance; they are the first to treat the computational needs of the biology community hand-in-hand with appropriate advances in artificial intelligence. Focusing on novel technologies and approaches, rather than on proven applications, they cover genetic sequence analysis, protein structure representation and prediction, automated data analysis aids, and simulation of biological systems. A brief introductory primer on molecular biology and Al gives computer scientists sufficient background to understand much of the biology discussed in the book. Lawrence Hunter is Director of the Machine Learning Project at the National Library of Medicine, National Institutes of Health.

Handbook of Computational Intelligence in Biomedical Engineering and Healthcare helps readers analyze and conduct advanced research in specialty healthcare applications surrounding oncology, genomics and genetic data, ontologies construction, bio-memetic systems, biomedical electronics, protein structure prediction, and biomedical data analysis. The book provides the reader with a comprehensive guide to advanced computational intelligence, spanning deep learning, fuzzy logic, connectionist systems, evolutionary computation, cellular automata, self-organizing systems, soft computing, and hybrid intelligent systems in biomedical and healthcare applications. Sections focus on important biomedical engineering applications, including biosensors, enzyme immobilization techniques, immuno-assays, and nanomaterials for biosensors and other biomedical techniques. Other sections cover gene-based solutions and applications through computational intelligence techniques and the impact of nonlinear/unstructured data on experimental analysis. - Presents a comprehensive handbook that covers an Introduction to Computational Intelligence in Biomedical Engineering and Healthcare, Computational Intelligence Techniques, and Advanced and Emerging Techniques in Computational Intelligence - Helps readers analyze and do advanced research in specialty healthcare applications - Includes links to websites, videos, articles and other online content to expand and support primary learning objectives

Covering a wide range of notions concerning hesitant fuzzy set and its extensions, this book provides a comprehensive reference to the topic. In the case where different sources of vagueness appear simultaneously, the concept of fuzzy set is not able to properly model the uncertainty, imprecise and vague information. In order to overcome such a limitation, different types of fuzzy extension have been introduced so far. Among them, hesitant fuzzy set was first introduced in 2010, and the existing extensions of hesitant fuzzy set have been encountering an increasing interest and attracting more and more attentions up to now. It is not an exaggeration to say that the recent decade has seen the blossoming of a larger set of techniques and theoretical outcomes for hesitant fuzzy set together with its extensions as well as applications.As the research has moved beyond its infancy, and now it is entering a maturing phase with increased numbers and types of extensions, this book aims to give a comprehensive review of such researches. Presenting the review of many and important types of hesitant fuzzy extensions, and including references to a large number of related publications, this book will serve as a useful reference book for researchers in this field.

Bio-inspired computational algorithms are always hot research topics in artificial intelligence communities. Biology is a bewildering source of inspiration for the design of intelligent artifacts that are capable of efficient and autonomous operation in unknown and changing environments. It is difficult to resist the fascination of creating artifacts that display elements of lifelike intelligence, thus needing techniques for control, optimization, prediction, security, design, and so on. Bio-Inspired Computational Algorithms and Their Applications is a compendium that addresses this need. It integrates contrasting techniques of genetic algorithms, artificial immune systems, particle swarm optimization, and hybrid models to solve many real-world problems. The works presented in this book give insights into the creation of innovative improvements over algorithm performance, potential applications on various practical tasks, and combination of different techniques. The book provides a reference to researchers, practitioners, and students in both artificial intelligence and engineering communities, forming a foundation for the development of the field.