The artificial celestial body Aposimz measures 120,000 km in diameter. Most of its volume is its core space, which is covered by a superstructural shell. Fifty centuries ago, the people who lost the war against the core lost their right to reside legitimately on Aposimz, and were stranded on the frigid surface. They face rampant Frame Disease and aggressive automatons which appear frequently on the Ruins Level. Yet even so, somehow the people survive.

While their fight against the Empire continues, Titania uses her sensing abilities to track King Kajiwan as he heads toward the forbidden place known as the Gosabyo. During their pursuit of Kajiwan, Titania and her allies encounter strange phenomenon and notice the Rebedoan army behaving in mysterious ways. The culprit turns out to be the terrifying power wielded by Emperor Nichiko Suou…

Searching for the key to save a world beyond hope. Tsutomu Nihei's sci-fi horror epic! In Tsutomu Nihei's nightmare vision of the future, the N5S virus has swept across the earth, turning most of the population into zombie-like drones. Zoichi Kanoe, an agent of Toa Heavy Industry, is humanity's last hope, and he's not even human! With the help of Fuyu, a digitized intelligence built into the computer system of his Heavy Dual Coil motorcycle, Zoichi's search for the key to salvation will take him on a journey across surreal landscapes and hurl him into battle against mind-bending evil. Prepare yourself for the ultimate trip--prepare yourself for the world of BIOMEGA. After capturing Eon Green, DRF forces are amassing around Toa Heavy Industry headquarters and have taken Dr. Kurokawa and his daughter into custody. Zoichi must attempt a rescue--Dr. Kurokawa's laboratory may yield critical information on Eon Green. Elsewhere, Toa Heavy Industry agent Nishu Mizunoe searches for Kozlov Grebnev and the secrets he knows about the DRF's research, origins and their apocalyptic plan for the entire human race!

This story takes place on the frigid, massive artificial planet known as Aposimz. Eo, Biko and Etherow, residents of the White Diamond Beam, are in the middle of combat training when suddenly a girl appears, Rebedoan Empire soldiers in hot pursuit. The girl asks for their help in keeping safe a “code” and seven mysterious “bullets.” This chance encounter marks a major shift in the fate of the entire planet…

The Administration contacts Kyrii and Cibo, encouraging them to keep searching for the Net Terminal Gene which will stop the City from its intractable, chaotic growth. The Admin also warns them of the autonomous Safeguards, vicious entities that attempt to kill off any humans who access the Netsphere without the required Net Terminal Gene. Kyrii is attacked, and a group of humans who have settled on the outskirts of Toha Heavy Industries comes to his aid. Kyrii awakens with a newfound ability to read his surroundings, which allows him mere seconds to fend off an attacker lurking among the humans settlement. In the ensuing battle, Cibo makes a heavy sacrifice, but not before learning a startling truth about her traveling companion...

Keisha and Titania continue to hunt down Regular Frames in order to speed along Etherow’s recovery. As Kajiwan creates Regenerateds from those afflicted with Frame Disease, the Empire deploys new weapons in its fight against both Titania’s party and the True Core Church. When the Emperor himself makes a surprise appearance, Titania takes a chance that alters the future…

Kajiwan’s overreaching ambition ended in failure, and the weather-regulating satellite Ume crashed out of orbit. Etherow, who had held on to a sliver of hope that he could defeat Emperor Nichiko Suou, was badly injured and left barely clinging to life when Ume crashed to the surface. In the aftermath of Ume’s crash, the Northern Composite Slab Region grows ever colder, and a new energy begins to rise…

The population of Frame Disease sufferers continues to explode, and the Empire finds itself on the brink of collapse. As the conflict between Etherow’s party and the Execution Squad takes a very dark turn, the stage for the final, intense battle is set. In this final volume, the secrets of the planet Aposimz and the truth behind the folklore about the Core world are revealed…

The artificial celestial body Aposimz measures 120,000 km in diameter. Most of its volume is its core space, which is covered by a superstructural shell. Fifty centuries ago, the people who lost the war against the core lost their right to reside legitimately on Aposimz, and were stranded on the frigid surface. They face rampant Frame Disease and aggressive automatons which appear frequently on the Ruins Level. Yet even so, somehow the people survive.

In this final installment, Kyrii, still searching for the Net Terminal Gene, traces the steps of Cibo, reincarnated as a Level 9 Safeguard, and Sanakan, now a representative of the Administration. As Sanakan guides Cibo to a safe place where her sphere can develop in peace, Cibo is captured by the Silicon Life. Sanakan contacts Kyrii requesting his help in rescuing Cibo, because in her current form she may hold the key to saving the city. Sanakan risks everything in the battle against the Silicon Life. Kyrii arrives at a critical moment, and continues his endless journey while carrying the embodiment of hope for a different future beyond the outer limits of the city...