This valuable resource covers the principles of analytical instrumentation used by today's chemists and biologists and presents important advances in instrumentation, such as the drive to miniaturise and lab-on-a-chip devices. In terms of the lab-based analytical instrumentation, the five main categories of technique—spectroscopic, chromatographic, electrochemical, imaging and thermoanalytical, are included and presented in a practical, not theoretical way. Including relevant examples and applications in a number of fields such as healthcare, environment and pharmaceutical industry this book provides a complete overview of the instruments used within the chemistry industry, making this an important tool for professionals and students alike.

This treatment of process analytical technology, by a distinguished array of experts, chronicles over 50 years of process analyzer development - from its origin in the research laboratory at Ludwigshafen in the late 1930's to a dynamic worldwide technology in the early 1990s. Offering some theory and a lot of real-world, hands-on experience, this book is designed for field analyzer technicians, newly graduated engineers-in-training, and knowledgeable manufacturers application personnel. Included are drawings of sample systems that work and comments on ones that don't work. In addition, justifications and organization guidelines on process analyzer systems are presented. The volume describes analyzers from the systems side looking at implementation issues including justification, purchasing, training and validation. Specific analyzer types and the fundamentals of application for a variety of situations are explored.Contents: Introduction to This Technology Typical Analyzer Application Justifications Interfacing Analyzers With Systems Specification and Purchasing of Analyzers Calibration Considerations Training Aspects SPC/SQC for Analyzers Personnel and Organizational Issues Validation of Process Analyzers Sample Conditioning Systems Component Specific Analyzers Electrochemical Analyzers Compositional Analyzers Spectroscopic Analyzers Physical Property.

Instrumental Methods in Food Analysis is aimed at graduate students in the science, technology and engineering of food and nutrition who have completed an advanced course in food analysis. The book is designed to fit in with one or more such courses, as it covers the whole range of methods applied to food analysis, including chromatographic techniques (HPLC and GC), spectroscopic techniques (AA and ICP), electroanalytical and electrophoresis techniques. No analysis can be made without appropriate sample preparation and in view of the present economic climate, the search for new ways to prepare samples is becoming increasingly important. Guided by the need for environmentally-friendly technologies, the editors chose two, relatively new techniques, the microwave-assisted processes (MAPTM (Chapter 10) and supercritical fluid extraction (Chapter 11). Features of this book: - is one the few academic books on food analysis specifically designed for a one semester or one year course -it contains updated information - the coverage gives a good balance between theory, and applications of techniques to various food commodities. The chapters are divided into two distinct sections: the first is a description of the basic theory regarding the technique and the second is dedicated to a description of examples to which the reader can relate in his/her daily work.

This book will acquaint the interested physician or physicist with the fundamental principles and the instrumentation relevant to analytical techniques based on atomic and nuclear physics, as well as present and future biomedical applications. Besides providing a theoretical description of the physical phenomena, a large part of the book is devoted to applications in the medical and biological field, particularly in haematology, forensic medicine and environmental science.Analysis of the elemental composition of human tissues and cells and in particular trace elements has attracted increasing interest over the last few years, due to the increase in knowledge on the role of some elements and the possible correlations between abnormal concentrations of one or more trace elements and pathological conditions. This has stimulated the development of analytical techniques which allow the detection of trace elements simultaneously and at very low concentrations. Particularly in methods involving nuclear principles or nuclear apparatus, many techniques have been largely and successfully developed in recent years and applied in the medical field. This volume reviews methods such as the possibility of carrying out rapid multi-element analysis of trace elements on biomedical samples, in vitro and in vivo, by XRF-analysis; the ability of the PIXE-microprobe to analyze in detail and to map trace elements in fragments of biomedical samples or inside the cells; the potentiality of in vivo nuclear activation analysis for diagnostic purposes. Finally, techniques are described such as radiation scattering (elastic and inelastic scattering) and attenuation measurements which will undoubtedly see great development in the immediate future.

UV-Visible Spectrophotometry of Water and Wastewater is the first book dedicated to the use of UV spectrophotometry for water and wastewater quality monitoring. Using practical examples the reader is shown how this technique can be a source of new methods of characterization and measurement. Easy and fast to run, this simple and robust analytical technique must be considered as one of the best ways to obtain a quantitative estimation of specific or aggregate parameters (eg. Nitrate, TOC), and simultaneously qualitative information on the global composition of water and its variation.* First electronic library of UV-spectra providing data readily available for researchers and users* Provides a theoretical basis for further research in the field of spectra exploitation* Contains helpful practical applications

Completely revised and updated, Chemical Analysis: Second Edition is an essential introduction to a wide range of analytical techniques and instruments. Assuming little in the way of prior knowledge, this text carefully guides the reader through the more widely used and important techniques, whilst avoiding excessive technical detail. Provides a thorough introduction to a wide range of the most important and widely used instrumental techniques Maintains a careful balance between depth and breadth of coverage Includes examples, problems and their solutions Includes coverage of latest developments including supercritical fluid chromatography and capillary electrophoresis

This book is an updated, completely revised version of a previous volume in this series entitled: ENVIRONMENTAL ANALYSIS -- Techniques, applications and quality assurance. The book treats different aspects of environmental analysis such as sample handling and analytical techniques, the applications to trace analysis of pollutants (mainly organic compounds), and quality assurance aspects, including the use of certified reference materials for the quality control of the whole analytical process. New analytical techniques are presented that have been developed significantly over the last 6 years, like solid phase microextraction, microwave-assisted extraction, liquid chromatography-mass spectrometric methods, immunoassays, and biosensors. The book is divided into four sections. The first describes field sampling techniques and sample preparation in environmental matrices: water, soil, sediment and biota. The second section covers the application areas which are either based on techniques, like the use of gas chromatography-atomic emission detection, immunoassays, or coupled-column liquid chromatography, or on specific application areas, like chlorinated compounds, pesticides, phenols, mycotoxins, phytotoxins, radionuclides, industrial effluents and wastes, including mine waste. Validation and quality assurance are described in the third section, together with the interpretation of environmental data using advanced chemometric techniques. The final section reports the use of somewhat advanced analytical methods, usually more expensive, less routinely used or less developed, for the determination of pollutants.

This book is divided into 5 sections starting with an historic perspective and fundamental aspects on the synthesis and recognition by imprinted polymers. The second section contains 8 up-to-date overview chapters on current approaches to molecular and ion imprinting. This is followed by two chapters on new material morphologies and in the last two sections various analytical applications of imprinted polymers are given, with the last four chapters devoted to the promising field of imprinted polymers in chemical sensors.The authors of this volume have widely different backgrounds; mainly polymer chemistry, organic chemistry, biochemistry and analytical chemistry, which means that this book has an interdisciplinary character and should appeal to a broad audience.

Validation describes the procedures used to analyze pharmaceutical products so that the data generated will comply with the requirements of regulatory bodies of the US, Canada, Europe and Japan. Calibration of Instruments describes the process of fixing, checking or correcting the graduations of instruments so that they comply with those regulatory bodies. This book provides a thorough explanation of both the fundamental and practical aspects of biopharmaceutical and bioanalytical methods validation. It teaches the proper procedures for using the tools and analysis methods in a regulated lab setting. Readers will learn the appropriate procedures for calibration of laboratory instrumentation and validation of analytical methods of analysis. These procedures must be executed properly in all regulated laboratories, including pharmaceutical and biopharmaceutical laboratories, clinical testing laboratories (hospitals, medical offices) and in food and cosmetic testing laboratories.

Compiled by the editor of Dekker's distinguished Chromatographic Science series, this reader-friendly reference is as a unique and stand-alone guide for anyone requiring clear instruction on the most frequently utilized analytical instrumentation techniques. More than just a catalog of commercially available instruments, the chapters are wri