Nearly 44 million people have Alzheimer's or related dementia worldwide, according to the Alzheimer's Disease International organization. That number is expected to double every 20 years. Unlike other books on the market, Alzheimer's Disease: Understanding Biomarkers, Big Data, and Therapy covers recent advancements in cognitive, clinical, neural, and therapeutic aspects of Alzheimer's and other forms of dementia.First, readers are introduced to cognitive and clinical studies, focusing on the different types of memory impairment, past and future thinking. This includes the prevalence of depression, its relationship to other symptoms, and the quality of life for those with Alzheimer's disease. In addition, the book discusses recent studies on memory dysfunction in advanced-stage Alzheimer's disease, in comparison to early-stage, including a chapter on the underlying factors in the transition from mild cognitive impairment to Alzheimer's diagnosis. Following this section, the book presents recent studies on the role of different cortical and subcortical structures in the development of various symptoms in Alzheimer's disease, as well as different neural biomarkers underlying the development and treatment of the disease. In the last section of the book, therapeutic aspects of Alzheimer's disease, focusing on behavioral and pharmacological treatments of sleep disorders, memory problems, and depression, are reviewed. The book aids readers in understanding the advances in research and care, making it a prime tool for all clinicians, psychologists, researchers, neurologists, and caregivers of dementia patients. - Reviews recent developments of cognitive and clinical studies - Covers factors underlying the transition from mild cognitive impairment to Alzheimer's disease - Discusses different neural biomarkers underlying the development and treatment of Alzheimer's disease - Provides a comparison of the effectiveness of various types of treatments

A reference on preventing, treating, and coping with dementia, from “one of the most reliable, respected health resources that Americans have” (Publishers Weekly). This book from the world-renowned Mayo Clinic offers an update on what experts know about Alzheimer’s and related dementias, including the latest research into treatment and prevention, ways to live well with dementia, and recommendations for caregivers. While Alzheimer’s disease is the most common type of dementia, many related types also affect adults worldwide, causing loss of memory, reason, judgment, and other cognitive functions. Although the diseases that cause dementia have long been considered unrelenting and incurable, recent advances offer hope. This book includes information about: • What to expect of typical aging and what are the earliest signs of abnormal aging • Memory loss and other forms of cognitive impairment that may lead to dementia • Characteristic features of Alzheimer’s disease and related dementias, including frontotemporal degeneration, Lewy body dementia, and vascular cognitive impairment • The latest research on Alzheimer’s disease and related dementias • Caring for and supporting someone living with dementia Are there ways you can lower your risk? Can dementia be prevented? Can you live well with dementia? If so, how? You’ll find answers to these important questions and more in this book.

A definitive and compelling book on one of today's most prevalent illnesses. In 2020, an estimated 5.8 million Americans had Alzheimer’s, and more than half a million died because of the disease and its devastating complications. 16 million caregivers are responsible for paying as much as half of the $226 billion annual costs of their care. As more people live beyond their seventies and eighties, the number of patients will rise to an estimated 13.8 million by 2050. Part case studies, part meditation on the past, present and future of the disease, The Problem of Alzheimer's traces Alzheimer’s from its beginnings to its recognition as a crisis. While it is an unambiguous account of decades of missed opportunities and our health care systems’ failures to take action, it tells the story of the biomedical breakthroughs that may allow Alzheimer’s to finally be prevented and treated by medicine and also presents an argument for how we can live with dementia: the ways patients can reclaim their autonomy and redefine their sense of self, how families can support their loved ones, and the innovative reforms we can make as a society that would give caregivers and patients better quality of life. Rich in science, history, and characters, The Problem of Alzheimer's takes us inside laboratories, patients' homes, caregivers’ support groups, progressive care communities, and Jason Karlawish's own practice at the Penn Memory Center.

The guide tells you how to: Understand how AD changes a person Learn how to cope with these changes Help family and friends understand AD Plan for the future Make your home safe for the person with AD Manage everyday activities like eating, bathing, dressing, and grooming Take care of yourself Get help with caregiving Find out about helpful resources, such as websites, support groups, government agencies, and adult day care programs Choose a full-time care facility for the person with AD if needed Learn about common behavior and medical problems of people with AD and some medicines that may help Cope with late-stage AD

Now presented in full color, this updated edition of Memory Loss, Alzheimer's Disease, and Dementia is designed as a practical guide for clinicians that delivers the latest treatment approaches and research findings for dementia and related illnesses. Drs. Budson and Solomon — both key leaders in the field — cover the essentials of physical and cognitive examinations and laboratory and imaging studies, giving you the tools you need to consistently make accurate diagnoses in this rapidly growing area. Access in-depth coverage of clinically useful diagnostic tests and the latest treatment approaches. Detailed case studies facilitate the management of both common and uncommon conditions. Comprehensive coverage of hot topics such as chronic traumatic encephalopathy, in addition to new criteria on vascular dementia and vascular cognitive impairment. Includes new National Institute on Aging–Alzheimer's Association and DSM-5 criteria for Alzheimer’s Disease and Mild Cognitive Impairment. Learn how to use new diagnostic tests, such as the amyloid imaging scans florbetapir (Amyvid), flutemetamol (Vizamyl), and florbetaben (Neuraceq), which can display amyloid plaques in the living brains of patients. Updated case studies, many complete with videos illustrating common tests, clinical signs, and diagnostic features, are now incorporated into the main text as clinical vignettes for all major disorders. Brand-new chapters on how to approach the differential diagnosis and on primary progressive aphasia. Expert Consult eBook version included with purchase. This enhanced eBook experience allows you to search all of the text, figures, references, and videos from the book on a variety of devices.

The instant New York Times and Wall Street Journal bestseller A groundbreaking plan to prevent and reverse Alzheimer’s Disease that fundamentally changes how we understand cognitive decline. Everyone knows someone who has survived cancer, but until now no one knows anyone who has survived Alzheimer's Disease. In this paradigm shifting book, Dale Bredesen, MD, offers real hope to anyone looking to prevent and even reverse Alzheimer's Disease and cognitive decline. Revealing that AD is not one condition, as it is currently treated, but three, The End of Alzheimer’s outlines 36 metabolic factors (micronutrients, hormone levels, sleep) that can trigger "downsizing" in the brain. The protocol shows us how to rebalance these factors using lifestyle modifications like taking B12, eliminating gluten, or improving oral hygiene. The results are impressive. Of the first ten patients on the protocol, nine displayed significant improvement with 3-6 months; since then the protocol has yielded similar results with hundreds more. Now, The End of Alzheimer’s brings new hope to a broad audience of patients, caregivers, physicians, and treatment centers with a fascinating look inside the science and a complete step-by-step plan that fundamentally changes how we treat and even think about AD.

New edition, completely rewritten, with new chapters on endovascular surgery and mitochrondrial and ion channel disorders.

A guide to more successful communication for the millions of Americans caring for someone with dementia: “Offers a fresh approach and hope.”—NPR Revolutionizing the way we perceive and live with Alzheimer’s, Joanne Koenig Coste offers a practical approach to the emotional well-being of both patients and caregivers that emphasizes relating to patients in their own reality. Her accessible and comprehensive method, which she calls habilitation, works to enhance communication between care partners and patients and has proven successful with thousands of people living with dementia. Learning to Speak Alzheimer’s also offers hundreds of practical tips, including how to: · cope with the diagnosis and adjust to the disease’s progression · help the patient talk about the illness · face the issue of driving · make meals and bath times as pleasant as possible · adjust room design for the patient’s comfort · deal with wandering, paranoia, and aggression “A fine addition to Alzheimer's and caregiving collections.”—Library Journal (starred review) “Promises to transform not only the lives of patients but those of care providers…This book is a gift.”—Sue Levkoff, coauthor of Aging Well

Soul-searing, life-testing situations have what some call “fall-out blessings.” The book is about understanding some of the deeper lessons we are exposed to through caring for individuals with Alzheimer’s and other types of dementia. We all want a cure. But in the meantime, while this illness is still with us, how can we create a quality of life for each person in each stage of the disease? How can we look deeper into situations that, at first glance, look hopeless and destructive in order to find opportunities for insight, inspiration, and great understanding of ourselves and those we love? How can we allow the full measure of the experience to unfold and be felt with as much of ourselves as we can bring to bear? This book will help people caring for those going through the difficult dementia journey find a way, through the tumultuous waves, to remain awake and open to the blessing of a journey that opens the heart, nurtures compassion, and ultimately enables each of us to be better human beings. It is also for those brave individuals living with memory loss illnesses, so that they be supported and allowed to live their experience fully in their own unique way, to express themselves, to love and be loved, and to be sheltered from harm—that with each stage of the progression, those around the person with dementia find ways to emphasize the loved one’s remaining strengths rather than spotlight their weaknesses. A person with dementia has a whole and well spirit and, in the broadest sense, their brain is a vehicle of self-expression; it does not define their essence. Finally, this book addresses head on the final stage of the disease, when the brain has exhausted all its compensatory ability and the individual is no longer able to take part in regular day-to-day life. At this advanced stage of the disease process, people with dementia are in a deep, internal state that caregivers generally cannot access and share. It can be a very disheartening time. This internal state separates the person with dementia from those around them; however, rather than thinking of it as a prison wall separating the person with dementia from the caregiver, it may be more helpful to think of the person having retreated into a cloistered existence for a while, affording them the time needed by the soul to attend to deeper aspect of the self on a spiritual level. This phase also allows those around the person to honor the vessel, or body, that has housed the loved in in this life and prepare to let them go. When ready the individual will know the time to leave, and if allowed, will let go. Coming from a rich professional background in caring, Megan Carnarius clearly outlines the different stages of dementia and highlights many practical aspects of dementia care, suggesting accessible tools for family and professionals alike. She also addresses the more subtle, spiritual dimensions of this illness with much compassion and understanding, offering new insights into areas that have not been explored in other books on the disease.

When Tom DeBaggio turned fifty-seven in 1999, he thought he was about to embark on the relaxing golden years of retirement -- time to spend with his family, his friends, the herb garden he had spent decades cultivating and from which he made a living. Then, one winter day, he mentioned to his doctor during a routine exam that he had been stumbling into forgetfulness, making his work difficult. After that fateful visit, and a subsequent battery of tests over several months, DeBaggio joined the legion of twelve million others afflicted with Alzheimer's disease. But under such a curse, DeBaggio was also given one of the greatest gifts: the ability to chart the ups and downs of his own failing mind. Losing My Mind is an extraordinary first-person account of early onset Alzheimer's -- the form of the disease that ravages younger, more alert minds. DeBaggio started writing on the first day of his diagnosis and has continued despite his slipping grasp on one of life's greatest treasures, memory. In an inspiring and detailed account, DeBaggio paints a vivid picture of the splendor of memory and the pain that comes from its loss. Whether describing the happy days of a youth spent in a much more innocent time or evaluating how his disease has affected those around him, DeBaggio poignantly depicts one of the most important parts of our lives -- remembrance -- and how we often take it for granted. But to DeBaggio, memory is more than just an account of a time long past, it is one's ability to function, to think, and ultimately, to survive. As his life becomes reduced to moments of clarity, the true power of thought and his ability to connect to the world shine through, and in DeBaggio's case, it is as much in the lack of functioning as it is in the ability to function that one finds love, hope and the relaxing golden years of peace. At once an autobiography, a medical history and a testament to the beauty of memory, Losing My Mind is more than just a story of Alzheimer's, it is the captivating tale of one man's battle to stay connected with the world and his own life.